Technology Process of Thiophene,
5-chloro-2-methyl-3-[2-(2-methyl-5-phenyl-3-thienyl)-1-cyclopenten-1-yl]-
There total 6 articles about Thiophene,
5-chloro-2-methyl-3-[2-(2-methyl-5-phenyl-3-thienyl)-1-cyclopenten-1-yl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1,2-bis(5-chloro-2-methylthien-3-yl)cyclopent-1-ene;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
With
boric acid tributyl ester;
In
tetrahydrofuran; hexane;
bromobenzene;
With
tetrakis(triphenylphosphine) palladium(0); sodium carbonate;
In
tetrahydrofuran; hexane;
Heating;
DOI:10.1080/15421400590946398
- Guidance literature:
-
1,2-bis(5-chloro-2-methylthien-3-yl)cyclopent-1-ene;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at 20 ℃;
for 0.5h;
With
boric acid tributyl ester;
In
tetrahydrofuran; hexane;
at 20 ℃;
for 1h;
iodobenzene;
With
sodium carbonate; ethylene glycol;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; hexane;
for 3h;
Further stages.;
Heating;
DOI:10.1039/b700177k
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: aluminum (III) chloride / nitromethane / 3 h / 20 °C / Cooling with ice
2.1: titanium tetrachloride; pyridine; zinc / tetrahydrofuran / Inert atmosphere; Darkness
3.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / 20 °C / Darkness; Inert atmosphere
3.2: 1 h / Inert atmosphere; Darkness
3.3: 50 °C / Inert atmosphere; Darkness
With
pyridine; aluminum (III) chloride; n-butyllithium; titanium tetrachloride; zinc;
In
tetrahydrofuran; nitromethane; hexane;
3.3: |Suzuki Coupling;
DOI:10.1021/acs.inorgchem.8b00146
