methyl-4-(5-methyl-4-(2-(2-methyl-5-phenylthiophen-3-yl)cyclopent-1-enyl)thiophen-2-yl)benzoate

Base Information

• Chemical Name: methyl-4-(5-methyl-4-(2-(2-methyl-5-phenylthiophen-3-yl)cyclopent-1-enyl)thiophen-2-yl)benzoate
• CAS No.: 915090-66-3
• Molecular Formula: C₂₉H₂₆O₂S₂
• Molecular Weight: 470.656
• Mol file: 915090-66-3.mol

Synonyms:methyl-4-(5-methyl-4-(2-(2-methyl-5-phenylthiophen-3-yl)cyclopent-1-enyl)thiophen-2-yl)benzoate

Chemical Property of methyl-4-(5-methyl-4-(2-(2-methyl-5-phenylthiophen-3-yl)cyclopent-1-enyl)thiophen-2-yl)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl-4-(5-methyl-4-(2-(2-methyl-5-phenylthiophen-3-yl)cyclopent-1-enyl)thiophen-2-yl)benzoate

There total 1 articles about methyl-4-(5-methyl-4-(2-(2-methyl-5-phenylthiophen-3-yl)cyclopent-1-enyl)thiophen-2-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

3-(2-(5-chloro-2-methylthiophene-3-yl)cyclopent-1-enyl)-5-phenyl-2-methylthiophene (391895-16-2) + 4-methoxycarbonylphenyl bromide (619-42-1) → methyl-4-(5-methyl-4-(2-(2-methyl-5-phenylthiophen-3-yl)cyclopent-1-enyl)thiophen-2-yl)benzoate (915090-66-3)

Guidance literature:

3-(2-(5-chloro-2-methylthiophene-3-yl)cyclopent-1-enyl)-5-phenyl-2-methylthiophene; With tert.-butyl lithium; In tetrahydrofuran; pentane; for 1h;

With boric acid tributyl ester; In tetrahydrofuran; pentane; at 20 ℃; for 1h;

4-methoxycarbonylphenyl bromide; With sodium carbonate; ethylene glycol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; pentane; at 80 ℃;

DOI:10.1039/b608502d

Reference yield: 89.0%

methyl-4-(5-methyl-4-(2-(2-methyl-5-phenylthiophen-3-yl)cyclopent-1-enyl)thiophen-2-yl)benzoate (915090-66-3) → 4-(5-methyl-4-(2-(2-methyl-5-phenylthiophen-3-yl)cyclopent-1-enyl)thiophen-2-yl)benzoic acid (915090-67-4)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 10h;

DOI:10.1039/b608502d

Reference yield:

methyl-4-(5-methyl-4-(2-(2-methyl-5-phenylthiophen-3-yl)cyclopent-1-enyl)thiophen-2-yl)benzoate (915090-66-3) → 4-(5-methyl-4-(2-(2-methyl-5-phenylthiophen-3-yl)cyclopent-1-enyl)thiophen-2-yl)-N-propylbenzamide

Guidance literature:

Multi-step reaction with 2 steps

1.1: 89 percent / LiOH / methanol; tetrahydrofuran; H₂O / 10 h / 20 °C

2.1: N-methylmorpholine; 2-chloro-4,6-dimethoxytriazine / CH₂Cl₂ / 2 h / 0 °C

2.2: 43 percent / CH₂Cl₂ / 1 h / 0 °C

With 4-methyl-morpholine; lithium hydroxide; 2-chloro-4,6-dimethoxytriazine; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1039/b608502d

upstream raw materials:

3-(2-(5-chloro-2-methylthiophene-3-yl)cyclopent-1-enyl)-5-phenyl-2-methylthiophene

4-methoxycarbonylphenyl bromide

Downstream raw materials:

4-(5-methyl-4-(2-(2-methyl-5-phenylthiophen-3-yl)cyclopent-1-enyl)thiophen-2-yl)benzoic acid