4-Imidazolidinecarboxylic acid, 3-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-methyl-1-oxobutyl]-2- oxo-1-(phenylmethyl)-, phenylmethyl ester, (4S)-

Base Information

Chemical Name:4-Imidazolidinecarboxylic acid, 3-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-methyl-1-oxobutyl]-2- oxo-1-(phenylmethyl)-, phenylmethyl ester, (4S)-
CAS No.:393548-62-4
Molecular Formula:C₂₈H₃₅N₃O₆
Molecular Weight:509.602
Hs Code.:

4-Imidazolidinecarboxylic acid,
3-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-methyl-1-oxobutyl]-2-
oxo-1-(phenylmethyl)-, phenylmethyl ester, (4S)-

Synonyms:

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Chemical Property of 4-Imidazolidinecarboxylic acid, 3-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-methyl-1-oxobutyl]-2- oxo-1-(phenylmethyl)-, phenylmethyl ester, (4S)-

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Technology Process of 4-Imidazolidinecarboxylic acid, 3-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-methyl-1-oxobutyl]-2- oxo-1-(phenylmethyl)-, phenylmethyl ester, (4S)-

There total 4 articles about 4-Imidazolidinecarboxylic acid, 3-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-methyl-1-oxobutyl]-2- oxo-1-(phenylmethyl)-, phenylmethyl ester, (4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3392-12-9
Boc-Val-ONSu

: 89371-46-0
benzyl (4S)-1-benzyl-2-oxoimidazolidine-4-carboxylate

: 393548-62-4
(S)-1-Benzyl-3-((S)-2-tert-butoxycarbonylamino-3-methyl-butyryl)-2-oxo-imidazolidine-4-carboxylic acid benzyl ester

Guidance literature:: benzyl (4S)-1-benzyl-2-oxoimidazolidine-4-carboxylate; With potassium tert-butylate; In tetrahydrofuran; at -40 ℃;

Boc-Val-ONSu; In tetrahydrofuran; at -40 ℃;
DOI:10.1016/j.bmcl.2004.09.058

Reference yield:

: 100-39-0
benzyl bromide

: 393548-62-4
(S)-1-Benzyl-3-((S)-2-tert-butoxycarbonylamino-3-methyl-butyryl)-2-oxo-imidazolidine-4-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: K₂CO₃; TBAI / 1,2-dimethoxy-ethane

2.1: HBr; AcOH

3.1: KO-tBu / tetrahydrofuran / -40 °C

3.2: tetrahydrofuran / -40 °C

With potassium tert-butylate; hydrogen bromide; tetra-(n-butyl)ammonium iodide; potassium carbonate; acetic acid; In tetrahydrofuran; 1,2-dimethoxyethane;
DOI:10.1016/j.bmcl.2004.09.058

Reference yield:

: 89384-29-2
benzyl (4S)-3-(benzyloxycarbonyl)-2-oxoimidazolidine-4-carboxylate

: 393548-62-4
(S)-1-Benzyl-3-((S)-2-tert-butoxycarbonylamino-3-methyl-butyryl)-2-oxo-imidazolidine-4-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: K₂CO₃; TBAI / 1,2-dimethoxy-ethane

2.1: HBr; AcOH

3.1: KO-tBu / tetrahydrofuran / -40 °C

3.2: tetrahydrofuran / -40 °C

With potassium tert-butylate; hydrogen bromide; tetra-(n-butyl)ammonium iodide; potassium carbonate; acetic acid; In tetrahydrofuran; 1,2-dimethoxyethane;
DOI:10.1016/j.bmcl.2004.09.058