N-formyl-L-threonine

Base Information

• Chemical Name: N-formyl-L-threonine
• CAS No.: 93893-56-2
• Molecular Formula: C5H9 N O4
• Molecular Weight: 147.131
• Hs Code.: 2924199090
• Mol file: 93893-56-2.mol

Synonyms:N-formyl-L-threonine

Chemical Property of N-formyl-L-threonine

Chemical Property:

• Vapor Pressure: 4.54E-10mmHg at 25°C
• Boiling Point: 452°Cat760mmHg
• Flash Point: 227.1°C
• PSA: 90.12000
• Density: 1.336g/cm³
• LogP: -0.59330

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-formyl-L-threonine

There total 2 articles about N-formyl-L-threonine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

formic acid (64-18-6) + L-threonine (72-19-5,134357-96-3,7013-32-3,82822-12-6) → (2S,3R)-2-Formylamino-3-hydroxy-butyric acid (93893-56-2)

Guidance literature:

In acetic anhydride; for 12h; Ambient temperature;

Reference yield:

→ N-formyl-threonine (93893-56-2)

Guidance literature:

With sodium hydroxide;

DOI:10.1039/jr9500000062

Reference yield:

(2S,3R)-2-Formylamino-3-hydroxy-butyric acid (93893-56-2) → threophos (95421-90-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 22 percent / LiAlH₄ / tetrahydrofuran / 12 h / Ambient temperature

2: 54 percent / triethylamine / benzene / 12 h / Ambient temperature

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; benzene;

upstream raw materials:

formic acid

L-threonine

Downstream raw materials:

threophos

Refernces

• 1、 Masotti, Henriette,Peiffer, Gilbert,Siv, Chhan,Joblet, Elisabeth,Luu, Roger Phan Tan. "APPLICATION DE LA METHODOLOGIE DE LA RECHERCHE EXPERIMENTALE A LA SYNTHESE DU METHYLENE-2 VINYLCYCLOPENTANE PAR CYCLODIMERISATION DU BUTADIENE A L'AIDE DE COMPLEXES DU NICKEL". . p. 191 - 202. Retrieved 2007/10/02.