6-(Hydroxymethyl)pyridine-2-carboxaldehyde

Base Information

• Chemical Name: 6-(Hydroxymethyl)pyridine-2-carboxaldehyde
• CAS No.: 39621-11-9
• Molecular Formula: C7H7NO2
• Molecular Weight: 137.138
• Hs Code.: 2933399090
• Mol file: 39621-11-9.mol

Synonyms:2-carboxaldehyde-6-hydroxymethylpyridine;6-hydroxymethylpyridine-2-carboxylaldehyde;6-hydroxymethyl-2-pyridinecarboxaldehyde;

Chemical Property of 6-(Hydroxymethyl)pyridine-2-carboxaldehyde

Chemical Property:

• Vapor Pressure: 0.003mmHg at 25°C
• Melting Point: 73-74 °C
• Boiling Point: 274.472oC at 760 mmHg
• PKA: 13.05±0.10(Predicted)
• Flash Point: 119.797oC
• PSA: 50.19000
• Density: 1.268g/cm3
• LogP: 0.38640
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

6-(hydroxymethyl)pyridine-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(Hydroxymethyl)pyridine-2-carboxaldehyde

There total 8 articles about 6-(Hydroxymethyl)pyridine-2-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2.6-bis(hydroxymethyl)pyridine (1195-59-1) → 6-(hydroxymethyl)picolinaldehyde (39621-11-9)

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; at 65 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.chembiol.2019.03.007

Reference yield: 54.0%

2,6-Pyridinedicarboxaldehyde (5431-44-7) → 6-(hydroxymethyl)picolinaldehyde (39621-11-9)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.0833333h;

DOI:10.3987/com-02-s(m)44

Reference yield: 40.0%

2.6-bis(hydroxymethyl)pyridine (1195-59-1) → 2,6-Pyridinedicarboxaldehyde (5431-44-7) + 6-(hydroxymethyl)picolinaldehyde (39621-11-9)

Guidance literature:

With manganese(IV) oxide; In chloroform; for 5h; Inert atmosphere; Reflux;

DOI:10.1021/ol202959y

upstream raw materials:

2.6-bis(hydroxymethyl)pyridine

2-acetoxymethyl-6-diacetoxymethyl-pyridine

2,6-Pyridinedicarboxaldehyde

2,6-bis-acetoxymethyl-pyridine

Downstream raw materials:

6-hydroxymethyl-pyridine-2-carbaldehyde-(2,4-dinitro-phenylhydrazone)

6-hydroxymethylpyridine-2-yl(3,4,6-tri-O-benzyl-2-deoxy-2-nitro-β-D-glucopyranosyl)methanone

2,6-anhydro-3-deoxy-1-C-(6-hydroxymethyl-2-pyridyl)-4,5,7-tris-O-(phenylmethyl)-D-arabino-hept-2-enose

Refernces

• 1、 Lavalette, Arnaud,Tuna, Floriana,Clarkson, Guy,Alcock, Nathaniel W.,Hannon, Michael J.. "Aggregation of metallo-supramolecular architectures by metallo-assembled hydrogen bonding sites". . p. 2666 - 2667. Retrieved 2003.
• 2、 Ziessel, Raymond,Nguyen, Patrick. "An easy entry into Schiff base molecules bearing a pendant primary alcohol function for hydrogen bonding". . p. 223 - 232. Retrieved 2005.
• 3、 Griswold, Andrew R.,Cifani, Paolo,Rao, Sahana D.,Axelrod, Abram J.,Miele, Matthew M.,Hendrickson, Ronald C.,Kentsis, Alex,Bachovchin, Daniel A.. "A Chemical Strategy for Protease Substrate Profiling". . p. 901 - 6,907. Retrieved 2019.
• 4、 Manandhar, Erendra,Johnson, Ashley D. G.,Watson, William M.,Dickerson, Shelby D.,Sahukhal, Gyan S.,Elasri, Mohamed O.,Fronczek, Frank R.,Cragg, Peter J.,Wallace, Karl J.. "Detection of ferric ions in a gram-positive bacterial cell: Staphylococcus aureus". . p. 380 - 401. Retrieved 2020.
• 5、 Wu, Jianfeng,Liu, Dan,Yang, Qianqian,Ge, Yan,Tang, Jinkui,Qi, Zhenhui. "Magnetic investigation in di- And tetranuclear lanthanide complexes". supporting information. p. 2200 - 2207. Retrieved 2021/02/06.
• 6、 -. "Adenosine receptor antagonists". Paragraph 0165-0167. . Retrieved 2020/12/15.