METHYL 4-(4-METHYLPHENYL)-2,4-DIOXOBUTANOATE

Base Information

• Chemical Name: METHYL 4-(4-METHYLPHENYL)-2,4-DIOXOBUTANOATE
• CAS No.: 39757-29-4
• Molecular Formula: C12H12O4
• Molecular Weight: 220.225
• Hs Code.: 2918300090
• Mol file: 39757-29-4.mol

Synonyms:2,4-Dioxo-4-p-tolyl-butyric acid methyl ester;F1727-0237;p-toluylpyruvic acid methyl ester;methyl ester of 4-methylbenzoylpyruvic acid;methyl 2,4-dioxo-4-p-tolylbutanoate;Methyl 4-methyl-a,g-dioxo-benzenebutanoate;

Chemical Property of METHYL 4-(4-METHYLPHENYL)-2,4-DIOXOBUTANOATE

Chemical Property:

• PSA: 60.44000
• LogP: 1.30990
• Storage Temp.: 2-8°C

Purity/Quality:

99.5% ^*data from raw suppliers

methyl4-(4-methylphenyl)-2,4-dioxobutanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 4-(4-METHYLPHENYL)-2,4-DIOXOBUTANOATE

There total 5 articles about METHYL 4-(4-METHYLPHENYL)-2,4-DIOXOBUTANOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.8%

Dimethyl oxalate (553-90-2) + para-methylacetophenone (122-00-9) → methyl 2,4-dioxo-4-p-tolylbutanoate (39757-29-4)

Guidance literature:

Dimethyl oxalate; With potassium tert-butylate; In tetrahydrofuran; for 0.333333h; Molecular sieve; Cooling with ice; Inert atmosphere;

para-methylacetophenone; In tetrahydrofuran; for 6h; Cooling with ice;

Reference yield: 46.0%

para-methylacetophenone (122-00-9) + oxalic acid diethyl ester (95-92-1) → methyl 2,4-dioxo-4-p-tolylbutanoate (39757-29-4)

Guidance literature:

With methanol; sodium; In tert-butyl methyl ether; for 0.75h;

Reference yield:

2-methylamino-4-oxo-4-p-tolyl-crotononitrile → methyl 2,4-dioxo-4-p-tolylbutanoate (39757-29-4)

Guidance literature:

With hydrogenchloride;

upstream raw materials:

hydrogenchloride

methanol

water

Dimethyl oxalate

Downstream raw materials:

OC₆H₄OB(CH₃C₆H₄COCHCOCOOCH₃)

1-(4-cyanopyridin-2-yl)-5-(4-methylphenyl)-1H-pyrazole-3-carboxylic acid

tert-butyl [1-(4-cyanopyridin-2-yl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]carbamate

2-[3-amino-5-(4-methylphenyl)-1H-pyrazol-1-yl]pyridine-4-carboxylic acid

Refernces

• 1、 Jaiswal, Pradeep K.,Sharma, Vashundhra,Kumar, Surendra,Mathur, Manas,Swami, Ajit K.,Yadav, Dharmendra K.,Chaudhary, Sandeep. "Non-peptide-based new class of platelet aggregation inhibitors: Design, synthesis, bioevaluation, SAR, and in silico studies". . . Retrieved 2018/03/21.
• 2、 -. "HISTONE DEMETHYLASE INHIBITORS". Paragraph 00458; 00459. . Retrieved 2014/06/24.