THIOPHENE-2-CARBOXYLIC ACID (4-AMINO-PHENYL)-AMIDE

Base Information

• Chemical Name: THIOPHENE-2-CARBOXYLIC ACID (4-AMINO-PHENYL)-AMIDE
• CAS No.: 39880-86-9
• Molecular Formula: C11H10N2OS
• Molecular Weight: 218.279
• Mol file: 39880-86-9.mol

Synonyms:N-(4-aminophenyl)thiophene-2-carboxamide;Thiophene-2-carboxylic acid (4-amino-phenyl)-amide;Thiophen-2-carbonsaeure-4'-aminoanilid;4'-aminothiophene-2-carboxanilide;

Chemical Property of THIOPHENE-2-CARBOXYLIC ACID (4-AMINO-PHENYL)-AMIDE

Chemical Property:

• Melting Point: 164 - 165 °C
• PSA: 83.36000
• LogP: 3.23680

Purity/Quality:

98% ,99% , ^*data from raw suppliers

Thiophene-2-carboxylic acid (4-amino-phenyl)-amide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of THIOPHENE-2-CARBOXYLIC ACID (4-AMINO-PHENYL)-AMIDE

There total 8 articles about THIOPHENE-2-CARBOXYLIC ACID (4-AMINO-PHENYL)-AMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.9%

N-(4-nitrophenyl)thiophene-2-carboxamide (39880-88-1) → N-(4-aminophenyl)thiophene-2-carboxamide (39880-86-9)

Guidance literature:

With hydrogen; In tetrahydrofuran; ethanol; at 20 ℃;

Reference yield:

2-thiophenylcarboxylic acid (527-72-0) + 1,4-phenylenediamine (106-50-3) → N-(4-aminophenyl)thiophene-2-carboxamide (39880-86-9)

Guidance literature:

2-thiophenylcarboxylic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃; for 0.0833333h; Inert atmosphere;

1,4-phenylenediamine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2015.06.039

Reference yield:

{4-[(Thiophene-2-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester → N-(4-aminophenyl)thiophene-2-carboxamide (39880-86-9)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h;

DOI:10.1111/cbdd.12529

upstream raw materials:

N-(4-nitrophenyl)thiophene-2-carboxamide

4-nitro-aniline

2-Thiophenecarbonyl chloride

1,4-phenylenediamine

Downstream raw materials:

4-amino-3-[4-[(2-thienylcarbonyl)amino]phenylazo]-1-naphthalenesulfonic acid sodium salt

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