N-(4-nitrophenyl)thiophene-2-carboxamide

Base Information

Chemical Name:N-(4-nitrophenyl)thiophene-2-carboxamide
CAS No.:39880-88-1
Molecular Formula:C11H8N2O3S
Molecular Weight:248.262
Hs Code.:
DSSTox Substance ID:DTXSID701275039
Mol file:39880-88-1.mol

Synonyms:N-(4-nitrophenyl)thiophene-2-carboxamide;39880-88-1;N-(4-nitrophenyl)-2-thiophenecarboxamide;SCHEMBL6956119;DTXSID701275039;MFCD00171151;STK128450;AKOS000629501;MS-6798;CS-0327459;N-(4-NITROPHENYL)-2-THIENYLFORMAMIDE;SR-01000392629;SR-01000392629-1

Suppliers and Price of N-(4-nitrophenyl)thiophene-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of N-(4-nitrophenyl)thiophene-2-carboxamide

Chemical Property:

Melting Point:221 - 223 °C
PSA：103.16000
LogP:3.50480
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:248.02556330
Heavy Atom Count:17
Complexity:298

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CSC(=C1)C(=O)NC2=CC=C(C=C2)[N+](=O)[O-]

Technology Process of N-(4-nitrophenyl)thiophene-2-carboxamide

There total 5 articles about N-(4-nitrophenyl)thiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 5271-67-0
2-Thiophenecarbonyl chloride

: 100-01-6,104810-17-5
4-nitro-aniline

: 39880-88-1
N-(4-nitrophenyl)thiophene-2-carboxamide

Guidance literature:: 2-Thiophenecarbonyl chloride; 4-nitro-aniline; With pyridine; In chloroform; at 0 ℃; for 2h;

With hydrogenchloride; In chloroform; water;
DOI:10.1080/07391102.2016.1268071

Reference yield: 82.0%

: 98-03-3
thiophene-2-carbaldehyde

: 100-01-6,104810-17-5
4-nitro-aniline

: 39880-88-1
N-(4-nitrophenyl)thiophene-2-carboxamide

Guidance literature:: 4-nitro-aniline; With tert.-butylnitrite; trimethylsilylazide; In tetrahydrofuran; at 0 ℃;

thiophene-2-carbaldehyde; With 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride; sodium t-butanolate; In tetrahydrofuran; at -25 ℃;
DOI:10.1039/c3cc40452h

Reference yield:

: 527-72-0
2-thiophenylcarboxylic acid

: 39880-88-1
N-(4-nitrophenyl)thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / 0.5 h / Heating

2: triethylamine / CH₂Cl₂ / 1 h / Heating

With thionyl chloride; triethylamine; In dichloromethane;
DOI:10.1002/jhet.5570390616