39880-88-1

Upstream product

• 73230-90-7 [(4-Nitro-phenylamino)-thiophen-2-yl-methyl]-phosphonic acid diphenyl ester 
• 5271-67-0 2-Thiophenecarbonyl chloride 
• 100-01-6 4-nitro-aniline 
• 98-03-3 thiophene-2-carbaldehyde 
• 527-72-0 2-thiophenylcarboxylic acid 

Downstream Products

• 39880-86-9 N-(4-aminophenyl)thiophene-2-carboxamide 
• 69658-60-2 4-amino-3-[4-[(2-thienylcarbonyl)amino]phenylazo]-1-naphthalenesulfonic acid sodium salt 

Relevant academic research and scientific papers

Design, synthesis, MTT assay, DNA interaction studies of platinum(II) complexes

The square planar Pt(II) complexes of the type [Pt(Ln)(Cl2)] (where Ln?=?L1?3?=?thiophene-2-carboxamide derivatives and L4?6?=?thiophene-2-carbothioamide derivatives) have been synthesized and characterized by physicochemical and various spectroscopic studies. MIC method was employed to inference the antibacterial potency of complexes in reference to free ligands and metal salt. Characteristic binding constant (Kb) and binding mode of complexes with calf thymus DNA (CT-DNA) were determined using absorption titration (0.76–1.61?×?105?M?1), hydrodynamic chain length assay and fluorescence quenching analysis, deducing the partial intercalative mode of binding. Molecular docking calculation displayed free energy of binding in the range of –260.06 to –219.63 kJmol?1. The nuclease profile of complexes towards pUC19 DNA shows that the complexes cleave DNA more efficiently compared to their respective metal salt. Cytotoxicity profile of the complexes on the brine shrimp shows that all the complex exhibit noteworthy cytotoxic activity with LC50 values ranging from 7.87 to 15.94?μg/mL. The complexes have been evaluated for cell proliferation potential in human colon carcinoma cells (HCT 116) and IC50 value of complexes by MTT assay (IC50?=?125–1000?μg/mL).

NAPHTHALENE DERIVATIVE

The present invention provides compounds which can regulate VCP activity. The present invention provides the compound of formula (I) (R is as defined in the description) or oxides, esters, prodrugs, pharmaceutically acceptable salts or solvates thereof. The compounds can regulate VCP activity, and thus are useful for treating VCP-mediated diseases such as neurodegenerative diseases.

A catalytic and tert-butoxide ion-mediated amidation of aldehydes with para-nitro azides

We report here a new catalytic reaction in which, para-nitro azides are acylated by aldehydes to produce amides and molecular nitrogen in a single step. The transformation is believed to proceed via an electron transfer process mediated by the tert-butoxide ion, and catalysed by a thiazolium salt derived species. The Royal Society of Chemistry 2013.

Determination of aromaticity indices of thiophene and furan by nuclear magnetic resonance spectroscopic analysis of their anilides

A series of m- and p-substituted anilides of benzoic acid, 2-thienoic acid, and 2-furoic acid were prepared and their 1H and 13C nmr spectroscopic characteristics were examined. In general, good correlations were observed between the chemical shifts of proton and carbon signals of the acyl aromatic rings and the Hammett σ. Plots of the chemical shift values of the carbonyl carbons of the benzanilides against those of the 2-thienamides and 2-furamides gave an excellent correlation and the values of the slopes are 0.79 and 0.52, respectively, in dimethyl sulfoxide-d6. The slopes could be considered as a set of aromaticity index.