N-(pyridin-2-yl)prop-2-enamide

Base Information

• Chemical Name: N-(pyridin-2-yl)prop-2-enamide
• CAS No.: 40000-69-9
• Molecular Formula: C8H8N2O
• Molecular Weight: 148.164
• DSSTox Substance ID: DTXSID30432779
• Nikkaji Number: J949.311E
• Wikidata: Q82246884
• ChEMBL ID: CHEMBL2426254
• Mol file: 40000-69-9.mol

Synonyms:N-(pyridin-2-yl)prop-2-enamide;40000-69-9;N-pyridin-2-ylprop-2-enamide;2-Propenamide, N-2-pyridinyl-;CHEMBL2426254;2-acrylamidopyridine;N-(2-pyridyl)acrylamide;SCHEMBL1147615;DTXSID30432779;BDBM50048525;MFCD00596317;AKOS009808678;VS-0119;CS-0162721;D80876;EN300-177239;Z440633578

Chemical Property of N-(pyridin-2-yl)prop-2-enamide

Chemical Property:

• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 148.063662883
• Heavy Atom Count: 11
• Complexity: 156

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C=CC(=O)NC1=CC=CC=N1

Technology Process of N-(pyridin-2-yl)prop-2-enamide

There total 2 articles about N-(pyridin-2-yl)prop-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-aminopyridine (504-29-0) + acryloyl chloride (814-68-6,25189-84-8) → N-(pyridin-2-yl)prop-2-enamide (40000-69-9)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1002/open.202000273

Reference yield: 39.0%

2-aminopyridine (504-29-0) + 2-chloropropionyl chloride (625-36-5) → N-(3-chloropropanoyl)-N-(pyridin-2-yl)prop-2-enamide (1444510-29-5) + 3-chloro-N-(pyridin-2-yl)-N-[3-(pyridin-2-ylamino)propanoyl]propanamide (1444510-37-5) + 3-chloro-N-(pyridin-2-yl)propanamide (128456-13-3) + N-(pyridin-2-yl)prop-2-enamide (40000-69-9)

Guidance literature:

2-aminopyridine; With sodium hydride; In tetrahydrofuran; mineral oil; for 6h; Inert atmosphere;

2-chloropropionyl chloride; In tetrahydrofuran; mineral oil; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2013.04.076

Reference yield: 65.0%

3-nitro-benzaldehyde (99-61-6) + N-(pyridin-2-yl)prop-2-enamide (40000-69-9) → N-(2-pyridyl)-3-hydroxy-2-methylene-3-(3-nitrophenyl) propionamide

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In N,N-dimethyl-formamide; for 72h;

DOI:10.1081/SCC-200054850

upstream raw materials:

2-aminopyridine

acryloyl chloride

2-chloropropionyl chloride

Downstream raw materials:

(E)-3-(7-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl)-N-(pyridin-2-yl)acrylamide

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