3-chloro-N-(pyridin-2-yl)propanamide

Base Information

• Chemical Name: 3-chloro-N-(pyridin-2-yl)propanamide
• CAS No.: 128456-13-3
• Molecular Formula: C₈H₉ClN₂O
• Molecular Weight: 184.625
• Mol file: 128456-13-3.mol

Synonyms:

Chemical Property of 3-chloro-N-(pyridin-2-yl)propanamide

Chemical Property:

• Boiling Point: 394.6±22.0 °C(Predicted)
• PKA: 12.89±0.70(Predicted)
• Density: 1.285±0.06 g/cm3(Predicted)

Purity/Quality:

98%min ^*data from raw suppliers

3-chloro-N-(pyridin-2-yl)propanamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-chloro-N-(pyridin-2-yl)propanamide

There total 3 articles about 3-chloro-N-(pyridin-2-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

2-aminopyridine (504-29-0) + 2-chloropropionyl chloride (625-36-5) → N-(3-chloropropanoyl)-N-(pyridin-2-yl)prop-2-enamide (1444510-29-5) + 3-chloro-N-(pyridin-2-yl)-N-[3-(pyridin-2-ylamino)propanoyl]propanamide (1444510-37-5) + 3-chloro-N-(pyridin-2-yl)propanamide (128456-13-3) + N-(pyridin-2-yl)prop-2-enamide (40000-69-9)

Guidance literature:

2-aminopyridine; With sodium hydride; In tetrahydrofuran; mineral oil; for 6h; Inert atmosphere;

2-chloropropionyl chloride; In tetrahydrofuran; mineral oil; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2013.04.076

Reference yield: 28.0%

2-aminopyridine (504-29-0) + [(3-Chloro-propionylamino)-methylene]-dimethyl-ammonium; perchlorate → 3-chloro-N-(pyridin-2-yl)propanamide (128456-13-3)

Guidance literature:

In acetonitrile; for 0.0833333h; Heating;

Reference yield:

2-aminopyridine (504-29-0) → 3-chloro-N-(pyridin-2-yl)propanamide (128456-13-3)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.bmc.2016.04.021

upstream raw materials:

2-aminopyridine

2-chloropropionyl chloride

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