2-(3-Chlorophenyl)aniline

Base Information

Chemical Name:2-(3-Chlorophenyl)aniline
CAS No.:400743-82-0
Molecular Formula:C12H10ClN
Molecular Weight:203.671
Hs Code.:
DSSTox Substance ID:DTXSID70373894
Wikidata:Q82162278

Synonyms:400743-82-0;2-(3-chlorophenyl)aniline;[1,1'-Biphenyl]-2-amine, 3'-chloro-;3'-chlorobiphenyl-2-amine;3'-Chloro-[1,1'-biphenyl]-2-amine;3'-Chloro-biphenyl-2-amine;3'-chloro[1,1'-biphenyl]-2-amine;SCHEMBL398850;DTXSID70373894;MFCD03424658;3'-CHLORO-BIPHENYL-2-YLAMINE;AKOS004113530;SB77566;SY279618;BB 0222450;CS-0284191;E86289;EN300-5074231;2-Amino-3 inverted exclamation mark -chlorobiphenyl

Suppliers and Price of 2-(3-Chlorophenyl)aniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 2-(3-Chlorophenyl)aniline

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:203.0501770
Heavy Atom Count:14
Complexity:183

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C2=CC(=CC=C2)Cl)N

Technology Process of 2-(3-Chlorophenyl)aniline

There total 5 articles about 2-(3-Chlorophenyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 63503-60-6
3-chlorophenylboronic acid

: 615-36-1
2-bromoaniline

: 400743-82-0
3′-chloro-[1,1′-biphenyl]-2-amine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; water; toluene; at 95 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jo9002536

Reference yield:

: 615-43-0
2-iodophenylamine

: 63503-60-6
3-chlorophenylboronic acid

: 400743-82-0
3′-chloro-[1,1′-biphenyl]-2-amine

Guidance literature:: With palladium diacetate; potassium carbonate; In water; acetone; at 65 ℃; Sealed tube; Inert atmosphere;
DOI:10.1021/acs.orglett.6b02071

Reference yield:

: 577-19-5
2-nitrophenyl bromide

: 400743-82-0
3′-chloro-[1,1′-biphenyl]-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene / 0.17 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere; Reflux

2.1: ammonium chloride; iron / water; isopropyl alcohol / Reflux; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; iron; potassium carbonate; ammonium chloride; In water; isopropyl alcohol; toluene; 1.1: |Suzuki Coupling / 1.2: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.5b00659