3-BROMO-2-METHYLPROPAN-1-OL

Base Information

• Chemical Name: 3-BROMO-2-METHYLPROPAN-1-OL
• CAS No.: 40145-08-2
• Molecular Formula: C4H9BrO
• Molecular Weight: 153.019
• Hs Code.: 2905599890
• Mol file: 40145-08-2.mol

Synonyms:1-Propanol,3-bromo-2-methyl;(S)-3-bromo-2-methyl-propanol;(S)-3-bromo-2-methyl-propan-1-ol;(S)-(+)-3-Bromo-2-methyl-1-propanol;3-Bromo-2-methyl-1-propanol;AB3182;

Chemical Property of 3-BROMO-2-METHYLPROPAN-1-OL

Chemical Property:

• Boiling Point: 81-82 °C(Press: 20 Torr)
• PKA: 14?+-.0.10(Predicted)
• PSA: 20.23000
• Density: 1.448±0.06 g/cm3(Predicted)
• LogP: 1.00970

Purity/Quality:

99% ^*data from raw suppliers

3-Bromo-2-methylpropan-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Bromo-2-methylpropan-1-ol acts as a reagent in the synthesis of the major metabolites of febuxostat.

Technology Process of 3-BROMO-2-METHYLPROPAN-1-OL

There total 12 articles about 3-BROMO-2-METHYLPROPAN-1-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(2S)-3-Bromo-2-methyl-1-((tetrahydropyran-2-yl)oxy)propane (236096-77-8) → 3-bromo-2-methyl propan-1-ol (40145-08-2)

Guidance literature:

With ammonium nitrate; Montmorillonite-K₁₀; for 0.05h; microwave irradiation;

DOI:10.1080/00397919908086448

Reference yield: 75.0%

1'-(3'-hydroxy-2'-methylpropyl) (1S)-10-camphorsulfonate → (R)-3-bromo-2-methyl-1-propanol (93381-28-3) + (S)-3-bromo-2-methyl-1-propanol (40145-08-2,88523-22-2,93381-28-3,98244-48-5)

Guidance literature:

With tetrabutylammomium bromide; Inert atmosphere; Schlenk technique; Heating;

DOI:10.1021/jo5025392

Reference yield:

2-methyl-1.3-propanediol (2163-42-0) → 3-bromo-2-methyl propan-1-ol (40145-08-2)

Guidance literature:

With N-Bromosuccinimide; triphenylphosphine; In dichloromethane; at 0 ℃; for 7h;

DOI:10.1016/j.tetlet.2021.153573

upstream raw materials:

3-bromo-2-methyl-propionic acid methyl ester

3-methyloxetane

(2S)-3-Bromo-2-methyl-1-((tetrahydropyran-2-yl)oxy)propane

1,4-dibromo-2-butene

Downstream raw materials:

(2-methyl-3-hydroxypropyl)triphenylphosphonium bromide

(+)-(S)-3-(4-chlorophenoxy)-2-methyl-1-propanol

(2S)-1-bromo-3-[(tert-butyldiphenylsilyl)oxy]-2-methylpropane

[(S)-(-)-3-hydroxy-2-methylpropyl]triphenylphosphonium bromide

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