L-Alanine, N-(phenylmethylene)-, methyl ester

Base Information

• Chemical Name: L-Alanine, N-(phenylmethylene)-, methyl ester
• CAS No.: 40216-71-5
• Molecular Formula: C11H13NO2
• Molecular Weight: 191.23
• Mol file: 40216-71-5.mol

Synonyms:N-benzylidene-D,L-alanine methyl ester;N-benzylidene-alanine methyl ester;(+/-)-2-(benzylidene-amino)-propionic acid methyl ester;methyl benzylidenealaninate;2-(benzylidene-amino)-propionic acid methyl ester;methyl (N-benzylidene)alaninate;

Chemical Property of L-Alanine, N-(phenylmethylene)-, methyl ester

Chemical Property:

• Boiling Point: 85 °C (0.063 mmHg)
• PSA: 38.66000
• LogP: 1.66700

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Alanine, N-(phenylmethylene)-, methyl ester

There total 10 articles about L-Alanine, N-(phenylmethylene)-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

L-alanine methyl ester hydrochloride (2491-20-5) + benzaldehyde (100-52-7) → 2-(benzylidene-amino)-propionic acid methyl ester (53933-42-9,112674-72-3,120328-90-7,40216-71-5)

Guidance literature:

L-alanine methyl ester hydrochloride; With magnesium sulfate; triethylamine; In dichloromethane; at 20 ℃; for 0.25h; Inert atmosphere;

benzaldehyde; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/jacs.7b04690

Reference yield: 98.0%

methyl 2-aminopropanoate monohydrochloride (13515-97-4) + benzaldehyde (100-52-7) → methyl 2-(benzylideneamino)propanoate (40216-71-5)

Guidance literature:

methyl 2-aminopropanoate monohydrochloride; With magnesium sulfate; In dichloromethane; at 20 ℃; for 0.333333h; Inert atmosphere;

benzaldehyde; With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2010.03.107

Reference yield: 93.0%

benzaldehyde (100-52-7) → 2-(benzylidene-amino)-propionic acid methyl ester (53933-42-9,112674-72-3,120328-90-7,40216-71-5)

Guidance literature:

L-alanine methyl ester hydrochloride; With magnesium sulfate; triethylamine; In dichloromethane; for 0.166667h;

benzaldehyde; In dichloromethane; at 20 ℃;

upstream raw materials:

benzaldehyde

methanol

alanine hydrochloride

methyl 2-aminopropanoate monohydrochloride

Downstream raw materials:

3-Bromo-3,3-difluoro-2-methyl-2-{[1-phenyl-meth-(E)-ylidene]-amino}-propionic acid methyl ester

(E)-5-Methyl-5-{[1-phenyl-meth-(E)-ylidene]-amino}-hex-2-enedioic acid dimethyl ester

(1R,2R)-2-(1-Methoxycarbonyl-1-{[1-phenyl-meth-(E)-ylidene]-amino}-ethyl)-cyclopropanecarboxylic acid methyl ester

3-Chloro-2-methyl-2-{[1-phenyl-meth-(E)-ylidene]-amino}-propionic acid methyl ester