3-Benzofurancarboxylic acid, 2-methyl-, ethyl ester

Base Information

• Chemical Name: 3-Benzofurancarboxylic acid, 2-methyl-, ethyl ester
• CAS No.: 40484-97-7
• Molecular Formula: C12H12O3
• Molecular Weight: 204.225
• Mol file: 40484-97-7.mol

Synonyms:ethyl 2-methylbenzofuran-3-carboxylate;2-Methyl-benzofuran-3-carboxylic acid ethyl ester;3-Aethoxycarbonyl-2-methyl-cumaron;

Chemical Property of 3-Benzofurancarboxylic acid, 2-methyl-, ethyl ester

Chemical Property:

• Melting Point: 35 - 37 °C
• PSA: 39.44000
• LogP: 2.91790

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-Methylbenzofuran-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Benzofurancarboxylic acid, 2-methyl-, ethyl ester

There total 3 articles about 3-Benzofurancarboxylic acid, 2-methyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

O-phenylhydroxylamine (4846-21-3) + ethyl acetoacetate (141-97-9) → ethyl 2-methyl-1-benzofuran-3-carboxylate (40484-97-7) + phenol (108-95-2,27073-41-2)

Guidance literature:

With gold(III) chloride; silver hexafluoroantimonate; In nitromethane; at 90 ℃; for 8h; regioselective reaction; Inert atmosphere;

DOI:10.1021/jo101357d

Reference yield: 23.0%

2-(1,3-dioxolan-2-yl)phenol (6988-19-8) + ethyl 2-diazo-3-oxobutanoate (2009-97-4) → ethyl 2-methyl-1-benzofuran-3-carboxylate (40484-97-7) + ethyl 2-[2-(1,3-dioxolan-2-yl)phenoxy]-3-oxobutanoate

Guidance literature:

With dirhodium tetraacetate; at 100 ℃; for 8h;

DOI:10.1134/S1070428018120059

Reference yield:

2-(1,3-dioxolan-2-yl)phenol (6988-19-8) + ethyl 2-diazo-3-oxobutanoate (2009-97-4) → ethyl 2-methyl-1-benzofuran-3-carboxylate (40484-97-7) + salicylaldehyde (90-02-8)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); at 100 ℃; for 8h;

DOI:10.1134/S1070428018120059

upstream raw materials:

O-phenylhydroxylamine

ethyl acetoacetate

2-(1,3-dioxolan-2-yl)phenol

ethyl 2-diazo-3-oxobutanoate

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