3-IodoMethyl-piperidine-1-carboxylic acid benzyl ester

Base Information

• Chemical Name: 3-IodoMethyl-piperidine-1-carboxylic acid benzyl ester
• CAS No.: 405090-65-5
• Molecular Formula: C14H18INO2
• Molecular Weight: 359.207
• Hs Code.: 2933399090
• Mol file: 405090-65-5.mol

Synonyms:1-Piperidinecarboxylic acid,3-(iodomethyl)-,phenylmethyl ester;3-Iodomethylpiperidine-1-carboxylic acid benzyl ester;

Chemical Property of 3-IodoMethyl-piperidine-1-carboxylic acid benzyl ester

Chemical Property:

• PSA: 29.54000
• LogP: 3.40810

Purity/Quality:

≥95% ^*data from raw suppliers

3-Iodomethyl-piperidine-1-carboxylicacidbenzylester 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-IodoMethyl-piperidine-1-carboxylic acid benzyl ester

There total 4 articles about 3-IodoMethyl-piperidine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

benzyl 3-(hydroxymethyl)-1-piperidinecarboxylate (39945-51-2,160706-61-6) → 3-iodomethylpiperidine-1-carboxylic acid benzyl ester (405090-65-5)

Guidance literature:

With 1H-imidazole; iodine; triphenylphosphine; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1021/jm051196m

Reference yield:

3-(hydroxymethy)piperidine (4606-65-9) → 3-iodomethylpiperidine-1-carboxylic acid benzyl ester (405090-65-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / Et₃N / CH₂Cl₂ / 20 °C

2: 97 percent / PPh₃; I₂; imidazole / CH₂Cl₂ / 4 h / 20 °C

With 1H-imidazole; iodine; triethylamine; triphenylphosphine; In dichloromethane;

DOI:10.1021/jm051196m

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → 3-iodomethylpiperidine-1-carboxylic acid benzyl ester (405090-65-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / Et₃N / CH₂Cl₂ / 20 °C

2: 97 percent / PPh₃; I₂; imidazole / CH₂Cl₂ / 4 h / 20 °C

With 1H-imidazole; iodine; triethylamine; triphenylphosphine; In dichloromethane;

DOI:10.1021/jm051196m

upstream raw materials:

benzyl 3-(hydroxymethyl)-1-piperidinecarboxylate

3-(hydroxymethy)piperidine

benzyl chloroformate

Downstream raw materials:

3-(2-oxo-2H-pyridin-1-ylmethyl)piperidine-1-carboxylic acid benzyl ester

3-(4-Trifluoromethoxy-phenoxymethyl)-piperidine-1-carboxylic acid benzyl ester

Refernces

• 1、 Chellappan, Sheela K.,Xiao, Yingxian,Tueckmantel, Werner,Kellar, Kenneth J.,Kozikowski, Alan P.. "Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity". . p. 2673 - 2676. Retrieved 2007/10/03.
• 2、 -. "Method of treating addiction or dependence using a ligand for a monoamine receptor or transporter". . . Retrieved 2008/06/13.