Benzyl 3-(hydroxymethyl)piperidine-1-carboxylate

Base Information

Chemical Name:Benzyl 3-(hydroxymethyl)piperidine-1-carboxylate
CAS No.:39945-51-2
Molecular Formula:C14H19NO3
Molecular Weight:249.31
Hs Code.:29333990
DSSTox Substance ID:DTXSID70380200
Mol file:39945-51-2.mol

Synonyms:39945-51-2;benzyl 3-(hydroxymethyl)piperidine-1-carboxylate;N-CBZ-3-PIPERIDINEMETHANOL;1-Cbz-3-Hydroxymethylpiperidine;BENZYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE;1-Cbz-3-hydroxymethyl-piperidine;1-Piperidinecarboxylic acid, 3-(hydroxymethyl)-, phenylmethyl ester;3-Hydroxymethyl-piperidine-1-carboxylic acid benzyl ester;MFCD03407298;benzyl (3R)-3-(hydroxymethyl)piperidine-1-carboxylate;1-BENZYLOXYCARBONYL-3-PIPERIDINEMETHANOL;SCHEMBL1320424;DTXSID70380200;XLWOOUZKMJBINO-UHFFFAOYSA-N;N-Carbobenzyloxy-3-piperidinemethanol;AKOS009158455;CS-W012658;PB17305;PB22877;PB24322;SB10263;SS-3395;AC-22469;SY018381;1-benzyloxycarbonyl-3-piperidinyl methanol;1-(Benzyloxycarbonyl)piperidin-3-yl methanol;1-benzyloxycarbonyl-3-hydroxymethylpiperidine;A6670;AM20040384;FT-0622798;1-benzyloxycarbonyl-3-hydroxymethyl-piperidine;EN300-73816;benzyl3-(hydroxymethyl)piperidine-1-carboxylate;benzyl 3-(hydroxymethyl)-1-piperidinecarboxylate;Q-103022;3-Hydroxymethylpiperidine-1-carboxylic acid benzyl ester;Z352747426;BENZYL3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE;Benzyl 3-(hydroxymethyl)tetrahydro-1(2H)-pyridinecarboxylate, AldrichCPR

Suppliers and Price of Benzyl 3-(hydroxymethyl)piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Benzyl3-(Hydroxymethyl)piperidine-1-carboxylate
1g
$ 95.00

TRC
Benzyl3-(Hydroxymethyl)piperidine-1-carboxylate
5g
$ 250.00

Synthonix
1-Cbz-3-(hydroxymethyl)piperidine 95+%
25g
$ 160.00

SynQuest Laboratories
3-(Hydroxymethyl)piperidine, N-Cbz protected
1 g
$ 21.00

Matrix Scientific
Benzyl 3-(hydroxymethyl)tetrahydro-1(2H)-pyridinecarboxylate
5g
$ 315.00

Matrix Scientific
Benzyl 3-(hydroxymethyl)tetrahydro-1(2H)-pyridinecarboxylate
1g
$ 91.00

J&W Pharmlab
1-Cbz-3-hydroxymethyl-piperidine 97%
25g
$ 4880.00

J&W Pharmlab
1-Cbz-3-hydroxymethyl-piperidine 97%
5g
$ 1998.00

J&W Pharmlab
1-Cbz-3-hydroxymethyl-piperidine 97%
1g
$ 598.00

Crysdot
Benzyl3-(hydroxymethyl)piperidine-1-carboxylate 95+%
10g
$ 112.00

Total 71 raw suppliers

Chemical Property of Benzyl 3-(hydroxymethyl)piperidine-1-carboxylate

Chemical Property:

Appearance/Colour:pale yellow oil.
Vapor Pressure:5.4E-07mmHg at 25°C
Melting Point:59-60℃
Refractive Index:1.549
Boiling Point:396.4 °C at 760 mmHg
PKA:14.93±0.10(Predicted)
Flash Point:193.5 °C
PSA：49.77000
Density:1.162 g/cm³
LogP:1.96540
Storage Temp.:2-8°C
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:249.13649347
Heavy Atom Count:18
Complexity:264

Purity/Quality:

99%, ^*data from raw suppliers

Benzyl3-(Hydroxymethyl)piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 36/37/38-36
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(CN(C1)C(=O)OCC2=CC=CC=C2)CO
Uses Benzyl 3-(Hydroxymethyl)piperidine-1-carboxylate is an intermediate used in the synthesis of disubstituted pyrimidines as Lck inhibitors.

Technology Process of Benzyl 3-(hydroxymethyl)piperidine-1-carboxylate

There total 8 articles about Benzyl 3-(hydroxymethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 4606-65-9
3-(hydroxymethy)piperidine

: 501-53-1,94274-21-2
benzyl chloroformate

: 39945-51-2,160706-61-6
benzyl 3-(hydroxymethyl)-1-piperidinecarboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; Cooling;
DOI:10.1016/j.bmc.2011.08.054

Reference yield: 92.0%

: 310454-53-6
3-ethyl 1-(phenylmethyl) 1,3-piperidinedicarboxylate

: 39945-51-2,160706-61-6
benzyl 3-(hydroxymethyl)-1-piperidinecarboxylate

Guidance literature:: 3-ethyl 1-(phenylmethyl) 1,3-piperidinedicarboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at -10 ℃; for 1h;

With sodium hydroxide; In tetrahydrofuran; water;