Technology Process of (3,4-Dihydro-2h-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone
There total 4 articles about (3,4-Dihydro-2h-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
7-bromo-3,4-dihydro-2H-pyrano[2,3-b]quinoline;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.5h;
N,4-dimethoxy-N-cis/trans-methylcyclohexanecarboxamide;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
DOI:10.1021/jm049499o
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: POCl3 / 6 h / 75 °C
2.1: 28 percent / aq. HCl / 10 h / Heating
3.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C
3.2: 35 percent / tetrahydrofuran; hexane / 1 h / -78 °C
With
hydrogenchloride; n-butyllithium; trichlorophosphate;
In
tetrahydrofuran; hexane;
1.1: Vilsmeier-Haack reaction;
DOI:10.1021/jm049499o
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 28 percent / aq. HCl / 10 h / Heating
2.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C
2.2: 35 percent / tetrahydrofuran; hexane / 1 h / -78 °C
With
hydrogenchloride; n-butyllithium;
In
tetrahydrofuran; hexane;
DOI:10.1021/jm049499o
