1,6-Naphthyridine-7-carboxamide, 5-bromo-N-[(4-fluorophenyl)methyl]-8-hydroxy-

Base Information

Chemical Name:1,6-Naphthyridine-7-carboxamide, 5-bromo-N-[(4-fluorophenyl)methyl]-8-hydroxy-
CAS No.:410544-56-8
Molecular Formula:C16H11BrFN3O2
Molecular Weight:376.185
Hs Code.:
Mol file:410544-56-8.mol

Synonyms:5-bromo-N-(4-fluorobenzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamide;5-Bromo-8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluoro-benzylamide;

Suppliers and Price of 1,6-Naphthyridine-7-carboxamide, 5-bromo-N-[(4-fluorophenyl)methyl]-8-hydroxy-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 1,6-Naphthyridine-7-carboxamide, 5-bromo-N-[(4-fluorophenyl)methyl]-8-hydroxy-

Chemical Property:

PSA：75.11000
LogP:3.55790

Purity/Quality:: 98%,99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses This product is Informer compound X10 of the Aryl Halide Chemistry Informer Library developed by chemists at Merck & Co., Inc., Kenilworth, NJ, U.S., which contains 18 drug-like molecules representative of those encountered in complex synthesis. By screening a new reaction against the Informer Library, chemists can directly compare and analyse a reaction′s successes and shortcomings among different methods and various research teams. It may also be used to facilitate deeper method development for performance or utility.

Technology Process of 1,6-Naphthyridine-7-carboxamide, 5-bromo-N-[(4-fluorophenyl)methyl]-8-hydroxy-

There total 6 articles about 1,6-Naphthyridine-7-carboxamide, 5-bromo-N-[(4-fluorophenyl)methyl]-8-hydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 410544-37-5
5-bromo-8-hydroxy-[1,6]naphthyridine-7-carboxylic acid methyl ester

: 140-75-0
para-fluorobenzylamine

: 410544-56-8
N-(4-fluorobenzyl)-8-hydroxy-5-bromo-1,6-naphthyridine-7-carboxamide

Guidance literature:: In toluene; for 20h; Reflux;
DOI:10.1021/jm300667v

Reference yield:

: 124-63-0
methanesulfonyl chloride

: 140-75-0
para-fluorobenzylamine

: 410544-56-8
N-(4-fluorobenzyl)-8-hydroxy-5-bromo-1,6-naphthyridine-7-carboxamide

Guidance literature:: In toluene;

Reference yield:

: 699-98-9
Pyridine-2,3-dicarboxylic anhydride

: 410544-56-8
N-(4-fluorobenzyl)-8-hydroxy-5-bromo-1,6-naphthyridine-7-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: 16 h / Reflux

2: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 3 h / Reflux

3: sodium tetrahydroborate / tetrahydrofuran / 0 °C

4: magnesium sulfate; triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere

5: methanol / 3 h / 0 - 20 °C

6: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C

7: toluene / 20 h / Reflux

With sodium tetrahydroborate; N-Bromosuccinimide; thionyl chloride; magnesium sulfate; N,N-dimethyl-formamide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jm300667v