334477-60-0

Usage

Uses

Used in Pharmaceutical Industry:
(R)-N-Methyl-1-[3,5-bis(trifluoromethyl)phenyl]ethylamine is used as a key intermediate in the synthesis of various drugs, particularly for the development of antidepressant and antipsychotic medications. Its unique structure and properties contribute to the therapeutic effects of these medications.
Used in Organic Synthesis:
(R)-N-Methyl-1-[3,5-bis(trifluoromethyl)phenyl]ethylamine serves as a building block in the creation of more complex molecules, facilitating the development of novel chemical entities with potential applications in various industries.
Used in Research and Development:
(R)-N-Methyl-1-[3,5-bis(trifluoromethyl)phenyl]ethylamine is utilized in the study of organic chemistry, medicinal chemistry, and drug discovery, providing insights into the structure-activity relationships and the design of new therapeutic agents.

InChI:InChI=1/C11H11F6N/c1-6(18-2)7-3-8(10(12,13)14)5-9(4-7)11(15,16)17/h3-6,18H,1-2H3/t6-/m1/s1

Upstream product

• 895521-36-5 [(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl](methyl)amine L-malate 
• 1333317-69-3 N-(1-(3,5-bis(trifluoromethyl) phenyl)ethylidene)methanamine 
• 30071-93-3 3,5-bis(trifluoromethyl)phenyl methyl ketone 
• 1333317-70-6 (R)-N-(1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-N-methylacetamide 
• 1000614-08-3 (R)-1-(3,5-bis(trifluoromethyl)phenyl)-N-methylethanamine p-toluenesulfonate 
• 672906-99-9 C₁₉H₁₉F₆N 
• 935534-56-8 (R)-3,5-bis(trifluoromethyl)-α-methyl-N-methylbenzylamine L-(-)-malic acid salt 
• 737786-85-5 1-(3,5-bis(trifluoromethyl)phenyl)ethyl methanesulfonate 
• 74-89-5 methylamine 
• 672907-02-7 C₁₉H₁₉F₆N 

Downstream Products

• 645378-98-9 1,1-dimethylethyl-4-[3-[{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]-1-(2,4-dichlorophenyl)-3-oxopropyl]-4-fluoro-1-piperidinecarboxylate 
• 645379-00-6 1,1-dimethylethyl-4-[3-[{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]-1-(2,4-dichlorophenyl)-3-oxopropyl]-4-fluoro-1-piperidinecarboxylate 
• 645379-08-4 1,1-dimethylethyl-4-[3-[{(1R)-1-[3, 5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]-1-(4-fluoro-2-methylphenyl)-3-oxopropyl]-4-fluoro-1-piperidinecarboxylate 
• 645379-10-8 1,1-dimethylethyl-4-[3-[{(1R)-1-[3, 5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]-1-(4-fluoro-2-methylphenyl)-3-oxopropyl]-4-fluoro-1-piperidinecarboxylate 
• 645379-58-4 1,1-dimethylethyl-4-[3-[{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]-1-(4-fluorophenyl)-3-oxopropylidene]-1-piperidinecarboxylate 
• 645379-65-3 1,1-dimethylethyl-4-[3[{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]-1-(4-fluoro-2-methylphenyl)-3-oxopropyl]-3,6-dihydro-1(2H)-pyridinecarboxylate 
• 645379-66-4 1,1-dimethylethyl-4-[3[{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]-1-(4-fluoro-2-methylphenyl)-3-oxopropyl]-3,6-dihydro-1(2H)-pyridinecarboxylate 
• 645378-53-6 1,1-dimethylethyl-4-[3-[{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]-1-(4-fluorophenyl)-3-oxopropyl]-1-piperidinecarboxylate 
• 645378-52-5 1,1-dimethylethyl-4-[3-[{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]-1-(4-fluorophenyl)-3-oxopropyl]-1-piperidinecarboxylate 
• 645378-69-4 1,1-dimethylethyl-4-[3-[{(1R)-1-[3, 5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]-1-(4-fluorophenyl)-3-oxopropyl]-4-fluoro-1-piperidinecarboxylate 
• 645378-71-8 1,1-dimethylethyl-4-[3-[{(1R)-1-[3, 5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]-1-(4-fluorophenyl)-3-oxopropyl]-4-fluoro-1-piperidinecarboxylate 
• 644982-41-2 1,1-dimethylethyl 4-{2-[{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]-2-oxoethyl}-4-(4-fluoro-2-methylphenyl)-1-piperidinecarboxylate 
• 1000614-08-3 (R)-1-(3,5-bis(trifluoromethyl)phenyl)-N-methylethanamine p-toluenesulfonate 
• 815632-33-8 cis-RS,RS-2-(4-fluoro-2-methyl-phenyl)-3-hydroxymethyl-piperidine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methyl-amide 

Relevant academic research and scientific papers

NOVEL NEUROKININ 1 RECEPTOR ANTAGONIST COMPOUNDS

The present invention relates to a compound according to formula (A) wherein n is 1 or 2; R1 and R2 are independently hydrogen, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, CD3 or halogen; R3 is hydrogen, C(=O)OR7 or C1-4 alkyl optionally substituted with hyd

CATALYST COMPOUNDS

The present invention relates to compounds, particularly but not exclusively, compounds for use as catalysts, methods for producing said compounds and the use of said compounds as catalysts in catalytic processes including, but not limited to, the asymmetric reduction of imine and enamine compounds and/or the reductive amination of ketone compounds. The compounds have the formula 1 wherein: R1, R2, R3, R4 and R5 are each separately selected from the group consisting of hydrogen, alkyl and aryl; X is oxygen or sulfur; W is selected from the group consisting of – OR18,–SR18, –NR19R20, –PR19R20 where R18 is alkyl or aryl, and R19 and R20 are each separately selected from the group consisting of hydrogen, alkyl and aryl; and Z has the formula 2 wherein: R6 and R7 are each separately selected from the group consisting of hydrogen, alkoxy, nitro, halogen, alkyl and aryl, or R6 and R7 are linked to form a cyclic group; and Y is oxygen, sulfur or NR10 in which R10 is selected from the group consisting of hydrogen, alkyl and aryl.

Process for the production of chiral amines

The invention relates to a process for the preparation of optically active N-protected secondary amines by asymmetric hydrogenation in the presence of an optically active transition metal catalyst, one or more ligands, a nitrogen protecting reagent and optionally an additive, wherein the substrate is an imine.

METHOD FOR PRODUCING OPTICALLY ACTIVE 1-(FLUORO-, TRIFLUOROMETHYL- OR TRIFLUOROMETHOXY-SUBSTITUTED PHENYL)ALKYLAMINE N-MONOALKYL DERIVATIVE

There is provided a method for producing an optically active 1-(fluoro-, trifluoromethyl- or trifluoromethoxy-substituted phenyl)alkylamine N-monoalkyl derivative, which includes the steps of conducting reductive alkylation of an optically active secondary amine and a formaldehyde (including an equivalent thereof) or lower aldehyde in the presence of a transition metal catalyst under a hydrogen gas atmosphere, thereby converting the secondary amine to an optically active tertiary amine of the formula, and subjecting the tertiary amine to hydrogenolysis. The target optically active compound can be produced efficiently by this production method.

METHOD FOR PRODUCING OPTICALLY ACTIVE BENZYLAMINE DERIVATIVE

Disclosed is a method for producing an optically active benzylamine derivative which is useful as an intermediate for pharmaceutical products and the like. Specifically, an optically active benzylsulfonylamide derivative as a novel compound is obtained by

PROCESS FOR PREPARING N, N-SUBSTITUTED CARBAMOYL HALIDES

The invention relates to a new and useful process for preparing N,N-substituted carbamoyl halides from secondary amines, carbon dioxide, trialkylsilyl chloride and a halogenating agent.

CATALYST COMPOSITIONS AND THEIR USE IN THE DE-ENRICHMENT OF ENANTIOMERICALLY ENRICHED SUBSTRATES

There is provided a process for the de-enrichment of enantiomerically enriched compositions which comprises reacting an enantiomerically enriched composition comprising at least a first enantiomer or diastereomer of a substrate comprising a carbon-heteroatom bond, wherein the carbon is a chiral centre and the heteroatom is a group V heteroatom, in the presence of a catalyst system and optionally a reaction promoter to give a product composition comprising first and second enantiomers or diastereomers of the substrate having a carbon-heteroatom bond, the ratio of second to first enantiomer or disatereomer in the product composition being greater than the ratio of second to first enantiomer or disatereomer in the enantiomerically enriched composition. Preferred catalyst systems include transition metal halide complex of the formula MnXpYr wherein M is a transition metal; X is a halide; Y is a neutral optionally substituted hydrocarbyl complexing group, a neutral optionally substituted perhalogenated hydrocarbyl complexing group, or an optionally substituted cyclopentadienyl complexing group; and n, p and r are integers. The reaction promoter is preferably a halide salt.

OPTICALLY ACTIVE 1-(FLUORO-,TRIFLUOROMETHYL-OR TRIFLUOROMETHOXY-SUBSTITUTED PHENYL)ALKYLAMINE N-MONOALKYL DERIVATIVES AND PROCESS FOR PRODUCING SAME

An optically active 1-(fluoro-, trifluoromethyl- or trifluoromethoxy-substituted phenyl)alkylamine N-monoalkyl derivative represented by the formula [4] is produced by a process including (a) reacting an optically active secondary amine, represented by th