Dimethyl (2-oxo-5-phenylpentyl)phosphonate

Base Information

• Chemical Name: Dimethyl (2-oxo-5-phenylpentyl)phosphonate
• CAS No.: 41640-05-5
• Molecular Formula: C13H19O4P
• Molecular Weight: 270.26100
• Mol file: 41640-05-5.mol

Synonyms:dimethyl 2-oxo-5-phenylpentyl phosphonate;Phosphonic acid,(2-oxo-5-phenylpentyl)-,dimethyl ester;dimethyl 2-oxo-5-phenylpentanephosphonate;

Chemical Property of Dimethyl (2-oxo-5-phenylpentyl)phosphonate

Chemical Property:

• Boiling Point: 393.0±35.0 °C(Predicted)
• PSA: 62.41000
• Density: 1.131±0.06 g/cm3(Predicted)
• LogP: 3.06430

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Dimethyl (2-oxo-5-phenylpentyl)phosphonate

There total 5 articles about Dimethyl (2-oxo-5-phenylpentyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

1-iodo-5-phenylpentan-2-one (1365263-90-6) + phosphorous acid trimethyl ester (121-45-9) → dimethyl 2-oxo-5-phenylpentanephosphonate (41640-05-5)

Guidance literature:

In acetonitrile; at 20 ℃; for 2h; Reflux; Inert atmosphere;

DOI:10.1080/00397911.2010.539754

Reference yield:

1-phenyl-2-bromoethane (103-63-9) → dimethyl 2-oxo-5-phenylpentanephosphonate (41640-05-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: methanol; sodium / 1 h / 20 °C / Reflux; Inert atmosphere

1.2: 21 h / 20 °C / Reflux; Inert atmosphere

2.1: bromine / methanol / 2 h / -5 - 20 °C / Inert atmosphere

2.2: 1 h / 20 °C

3.1: sodium iodide / acetone / 4 h / 20 °C / Inert atmosphere

4.1: acetonitrile / 2 h / 20 °C / Reflux; Inert atmosphere

With methanol; bromine; sodium; sodium iodide; In methanol; acetone; acetonitrile;

DOI:10.1080/00397911.2010.539754

Reference yield:

5-phenyl-2-pentanone (2235-83-8) → dimethyl 2-oxo-5-phenylpentanephosphonate (41640-05-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: bromine / methanol / 2 h / -5 - 20 °C / Inert atmosphere

1.2: 1 h / 20 °C

2.1: sodium iodide / acetone / 4 h / 20 °C / Inert atmosphere

3.1: acetonitrile / 2 h / 20 °C / Reflux; Inert atmosphere

With bromine; sodium iodide; In methanol; acetone; acetonitrile;

DOI:10.1080/00397911.2010.539754

upstream raw materials:

1-iodo-5-phenylpentan-2-one

phosphorous acid trimethyl ester

5-phenyl-2-pentanone

1-phenyl-2-bromoethane

Refernces