(6R-(6alpha,7beta(Z)))-3-(Acetoxymethyl)-7-((2-(chloroacetamido)thiazol-4-yl)(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid

Base Information

Chemical Name:(6R-(6alpha,7beta(Z)))-3-(Acetoxymethyl)-7-((2-(chloroacetamido)thiazol-4-yl)(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid
CAS No.:64486-19-7
Molecular Formula:C18H18 Cl N5 O8 S2
Molecular Weight:531.955
Hs Code.:
European Community (EC) Number:264-918-5
Nikkaji Number:J307.242H
Mol file:64486-19-7.mol

(6R-(6alpha,7beta(Z)))-3-(Acetoxymethyl)-7-((2-(chloroacetamido)thiazol-4-yl)(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid

Synonyms:EINECS 264-918-5;64486-19-7;(6R-(6alpha,7beta(Z)))-3-(Acetoxymethyl)-7-((2-(chloroacetamido)thiazol-4-yl)(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid;[6R-[6alpha,7beta(Z)]]-3-(acetoxymethyl)-7-[[2-(chloroacetamido)thiazol-4-yl](methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;C18H18ClN5O8S2;C18-H18-Cl-N5-O8-S2;(6R)-3-[(Acetyloxy)methyl]-7alpha-[[[2-[(chloroacetyl)amino]-4-thiazolyl][(Z)-methoxyimino]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Suppliers and Price of (6R-(6alpha,7beta(Z)))-3-(Acetoxymethyl)-7-((2-(chloroacetamido)thiazol-4-yl)(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 3 raw suppliers

Chemical Property of (6R-(6alpha,7beta(Z)))-3-(Acetoxymethyl)-7-((2-(chloroacetamido)thiazol-4-yl)(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid

Chemical Property:

PSA：237.11000
Density:1.777g/cm³
LogP:1.40030
XLogP3:-0.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:10
Exact Mass:531.0285326
Heavy Atom Count:34
Complexity:961

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)OCC1=C(N2C(C(C2=O)NC(=O)C(=NOC)C3=CSC(=N3)NC(=O)CCl)SC1)C(=O)O
Isomeric SMILES:CC(=O)OCC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)/C(=N/OC)/C3=CSC(=N3)NC(=O)CCl)SC1)C(=O)O

Technology Process of (6R-(6alpha,7beta(Z)))-3-(Acetoxymethyl)-7-((2-(chloroacetamido)thiazol-4-yl)(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid

There total 7 articles about (6R-(6alpha,7beta(Z)))-3-(Acetoxymethyl)-7-((2-(chloroacetamido)thiazol-4-yl)(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.2%

: 63527-52-6,152186-43-1
cefotaxime

: 79-04-9
chloroacetyl chloride

: 64486-19-7
7β-[2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]-3-acetoxymethyl-3-cephem-4-carboxylic acid

Guidance literature:: In N,N-dimethyl acetamide; at 20 ℃; for 1h;
DOI:10.1016/S0014-827X(03)00051-X

Reference yield:

: 68350-20-9
2-(2-chloroacetamidothiazol-4-yl)-2-(syn)-methoxyiminoacetyl chloride

: 957-68-6
7-Aminocephalosporanic acid

: 64486-19-7
7β-[2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]-3-acetoxymethyl-3-cephem-4-carboxylic acid

Guidance literature:: 2-(2-chloroacetamidothiazol-4-yl)-2-(syn)-methoxyiminoacetyl chloride; 7-Aminocephalosporanic acid; With sodium carbonate; In water; isopropyl alcohol; at -5 - 5 ℃; pH=6.5 - 7.5;

With hydrogenchloride; In water; isopropyl alcohol; pH=2.7 - 3.0;

Reference yield:

: 64486-18-6
2-(2-chloroacetylaminothiazole-4-yl)-2-(Z)-methoxyiminoacetic acid

: 67-64-1
acetone

: 3-acetoxymethyl-7-aminoceph-3-em-4-carboxylic acid

: 64486-19-7
7β-[2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]-3-acetoxymethyl-3-cephem-4-carboxylic acid

Guidance literature:: With hydrogenchloride; phosphorus pentachloride; bis-(trimethylsilyl)acetamide; triethylamine; In tetrahydrofuran; hexane; dichloromethane; water; ethyl acetate;