2'Chloro-4-methoxy benzoin

Base Information

• Chemical Name: 2'Chloro-4-methoxy benzoin
• CAS No.: 41841-04-7
• Molecular Formula: C15H13ClO3
• Molecular Weight: 276.719
• DSSTox Substance ID: DTXSID30471461
• Nikkaji Number: J1.809.995K
• Mol file: 41841-04-7.mol

Synonyms:2'chloro-4-methoxy benzoin;AGN-PC-00F50P;SCHEMBL10505939;DTXSID30471461

Chemical Property of 2'Chloro-4-methoxy benzoin

Chemical Property:

• PSA: 46.53000
• LogP: 3.26490
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 276.0553220
• Heavy Atom Count: 19
• Complexity: 300

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)C(C2=CC=CC=C2Cl)O

Technology Process of 2'Chloro-4-methoxy benzoin

There total 2 articles about 2'Chloro-4-methoxy benzoin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2-chloro-benzaldehyde (89-98-5) + 4-methoxy-benzaldehyde (123-11-5) → 2-(2-chlorophenyl)-2-hydroxy-1-(4-methoxyphenyl)ethanone (41841-04-7)

Guidance literature:

With 3-(2,6-diisopropylphenyl)-4,5-dimethylthiazol-3-ium perchlorate; triethylamine; In ethanol; at 60 ℃; for 22h; chemoselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201100870

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → 2-(2-chlorophenyl)-2-hydroxy-1-(4-methoxyphenyl)ethanone (41841-04-7)

Guidance literature:

In ethanol;

Reference yield: 96.0%

2-(2-chlorophenyl)-2-hydroxy-1-(4-methoxyphenyl)ethanone (41841-04-7) → 1-(2-chlorophenyl)-2-(4-methoxyphenyl)ethane-1,2-dione (41841-01-4)

Guidance literature:

With silica gel; ferric nitrate; In 1,2-dichloro-ethane; for 3h; Heating;

DOI:10.1081/SCC-120021976

upstream raw materials:

2-chloro-benzaldehyde

4-methoxy-benzaldehyde

Downstream raw materials:

2-(2-chlorophenyl)-1-(4-methoxyphenyl)ethanone

1-(2-chlorophenyl)-2-(4-methoxyphenyl)ethane-1,2-dione

1,2-dicyclohexylethane

meso-1,2-dicyclohexyl-ethane-1,2-diol

Refernces

• 1、 -. "2,3-Disubstituted-2,3,5,6,7,8-hexahydro-thiazolo[3,2-a]-[1,3]diazepin-3-ols". . . Retrieved 2008/06/13.