2'-Hydroxy-2,3-dimethoxychalcone

Base Information

• Chemical Name: 2'-Hydroxy-2,3-dimethoxychalcone
• CAS No.: 42220-80-4
• Molecular Formula: C17H16O4
• Molecular Weight: 284.30700
• DSSTox Substance ID: DTXSID501193035
• Mol file: 42220-80-4.mol

Synonyms:3-(2,3-Dimethoxyphenyl)-1-(2-hydroxyphenyl)-2-propen-1-one;DTXSID501193035;2'-hydroxy -2,3-dimethoxychalcone;FT-0772376

Chemical Property of 2'-Hydroxy-2,3-dimethoxychalcone

Chemical Property:

• Melting Point: 100～102℃
• Boiling Point: 453.2±45.0 °C(Predicted)
• PKA: 7.66±0.30(Predicted)
• PSA: 55.76000
• Density: 1.203±0.06 g/cm3(Predicted)
• LogP: 3.30550
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 284.10485899
• Heavy Atom Count: 21
• Complexity: 366

Purity/Quality:

98% ^*data from raw suppliers

2,3-Dimethoxy-2'-hydroxychalcone ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22
• Safety Statements: 26-36

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=CC(=C1OC)C=CC(=O)C2=CC=CC=C2O

Technology Process of 2'-Hydroxy-2,3-dimethoxychalcone

There total 3 articles about 2'-Hydroxy-2,3-dimethoxychalcone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

→ (E)-3-(2,3-dimethoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one (34000-33-4,42220-80-4)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 20 ℃;

Reference yield: 74.8%

o-hydroxyacetophenone (118-93-4,104809-67-8) + 2,3-dimethyoxybenzaldehyde (86-51-1) → 2'',3''-dimethoxy-2'-hydroxychalcone (42220-80-4)

Guidance literature:

With sodium hydroxide; In ethanol; for 48h;

Reference yield: 59.0%

o-hydroxyacetophenone (118-93-4,104809-67-8) + 2,3-dimethyoxybenzaldehyde (86-51-1) → (E)-3-(2,3-dimethoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one (34000-33-4,42220-80-4)

Guidance literature:

With potassium hydroxide; In ethanol; water;

DOI:10.1080/00397910802372517

upstream raw materials:

o-hydroxyacetophenone

2,3-dimethyoxybenzaldehyde

Downstream raw materials:

2-(2,3-dimethoxyphenyl)-4-(2-hydroxyphenyl)-2,3-dihydro-1H-1,5-benzodiazepine

2,3-dihydro-2-(2,3-dimethoxyphenyl)chromen-4-one

(Z)-2(2,3-dimethoxybenzylidene)benzofuran-3(2H)-one