2,4,5-Trichlorobenzoyl chloride

Base Information

• Chemical Name: 2,4,5-Trichlorobenzoyl chloride
• CAS No.: 42221-49-8
• Molecular Formula: C7H2Cl4O
• Molecular Weight: 243.904
• Hs Code.: 2916399090
• Mol file: 42221-49-8.mol

Synonyms:2,4,5-TRICHLOROBENZOYL CHLORIDE;

Chemical Property of 2,4,5-Trichlorobenzoyl chloride

Chemical Property:

• PSA: 17.07000
• LogP: 4.02580

Purity/Quality:

99% ^*data from raw suppliers

2,4,5-TrichlorobenzoylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,4,5-Trichlorobenzoyl Chloride is used in the preparation of quinazolines which acts as a MCH receptor antagonists, useful in treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure and more;Also, it is an intermediate used in the synthesis of 6-Chloro-6-defluoro Ciprofloxacin (C368035), which is an impurity of Ciprofloxacin (C482500), which is a fluorinated quinolone antibacterial.

Technology Process of 2,4,5-Trichlorobenzoyl chloride

There total 9 articles about 2,4,5-Trichlorobenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4,5-trichlorobenzoic acid (50-82-8) → 2,4,6-trichlorobenzoyl chloride (42221-49-8)

Guidance literature:

With thionyl chloride;

DOI:10.1039/jr9410000796

Reference yield:

benzoic acid (65-85-0,8013-63-6) → 2,4,6-trichlorobenzoyl chloride (42221-49-8)

Guidance literature:

Multi-step reaction with 2 steps

1: calcium chloride

2: PCl₅

With phosphorus pentachloride; calcium chloride;

Reference yield:

Hippuric Acid (495-69-2,140480-84-8,21251-67-2,91787-63-2,66407-11-2) → 2,4,6-trichlorobenzoyl chloride (42221-49-8)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrochloric acid; potassium chlorate

2: concentrated hydrochloric acid

3: calcium chloride

4: PCl₅

With hydrogenchloride; potassium chlorate; phosphorus pentachloride; calcium chloride;

upstream raw materials:

2,4,5-trichlorobenzoic acid

Hippuric Acid

3,4-Dichlorotoluene

3,4-dichlorbenzoic acid

Downstream raw materials:

2,4,5-trichloro-benzoic acid amide

2,4,5-trichloroacetophenone