N-methyl-3,5-bis(trifluoromethyl)aniline

Base Information

Chemical Name:N-methyl-3,5-bis(trifluoromethyl)aniline
CAS No.:42450-72-6
Molecular Formula:C9H7F6N
Molecular Weight:243.152
Hs Code.:2921430090
DSSTox Substance ID:DTXSID10549930
Wikidata:Q82429123
Mol file:42450-72-6.mol

Synonyms:42450-72-6;N-methyl-3,5-bis(trifluoromethyl)aniline;3,5-Bis(trifluoromethyl)-N-methylaniline;N1-METHYL-3,5-DI(TRIFLUOROMETHYL)ANILINE;SCHEMBL330354;DTXSID10549930;MFCD00119586;EN300-25169481;A1-20504;4-Phenyl-1-(4-tolylsulfonyl)piperidine-4-carboxylicacid

Suppliers and Price of N-methyl-3,5-bis(trifluoromethyl)aniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
3,5-BIS(TRIFLUOROMETHYL)-N-METHYLANILINE 95.00%
5MG
$ 502.65

American Custom Chemicals Corporation
3,5-BIS(TRIFLUOROMETHYL)-N-METHYLANILINE 95.00%
5G
$ 2348.85

A1 Biochem Labs
N-methyl-3,5-bis(trifluoromethyl)aniline 95%
5 g
$ 1200.00

Total 6 raw suppliers

Chemical Property of N-methyl-3,5-bis(trifluoromethyl)aniline

Chemical Property:

PSA：12.03000
LogP:3.83890
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:1
Exact Mass:243.04826820
Heavy Atom Count:16
Complexity:211

Purity/Quality:

99% ^*data from raw suppliers

3,5-BIS(TRIFLUOROMETHYL)-N-METHYLANILINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNC1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F

Technology Process of N-methyl-3,5-bis(trifluoromethyl)aniline

There total 7 articles about N-methyl-3,5-bis(trifluoromethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 75-52-5
nitromethane

: 69807-91-6
2-(3,5-bis-trifluoromethyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

: 42450-72-6
(3,5-bistrifluoromethylphenyl)(methyl)amine

Guidance literature:: With 1,2,2,3,4,4-hexamethylphosphetane 1-oxide; phenylsilane; at 120 ℃; for 24h; chemoselective reaction; Schlenk technique; Inert atmosphere;
DOI:10.1021/jacs.0c08035

Reference yield: 64.0%

: 26684-29-7
(3,5-bistrifluoromethylphenyl)carbamic acid tert-butyl ester

: 42450-72-6
(3,5-bistrifluoromethylphenyl)(methyl)amine

Guidance literature:: With lithium aluminium tetrahydride; In 1,4-dioxane; for 1.5h; Reflux;

Reference yield: 24.0%

: 328-74-5
3,5-Bis-(trifluoromethyl)aniline

: 149-73-5
trimethyl orthoformate

: 42450-72-6
(3,5-bistrifluoromethylphenyl)(methyl)amine

Guidance literature:: 3,5-Bis-(trifluoromethyl)aniline; trimethyl orthoformate; With sulfuric acid; In methanol; at 100 - 170 ℃; for 2.5h;

With hydrogenchloride; In methanol; water; for 3h; Reflux;
DOI:10.1021/acs.jmedchem.5b01510