(3-(3,5-Difluoropyridin-2-yl)-4-fluorophenyl)boronic acid

Base Information

Chemical Name:(3-(3,5-Difluoropyridin-2-yl)-4-fluorophenyl)boronic acid
CAS No.:425379-32-4
Molecular Formula:C11H7BF3NO2
Molecular Weight:252.988
Hs Code.:
DSSTox Substance ID:DTXSID60469831
Wikidata:Q82297719
Mol file:425379-32-4.mol

Synonyms:425379-32-4;(3-(3,5-Difluoropyridin-2-yl)-4-fluorophenyl)boronic acid;[3-(3,5-difluoropyridin-2-yl)-4-fluorophenyl]boronic acid;3-(3,5-difluoro-pyridin-2-yl)-4-fluorophenylboronic acid;starbld0019247;SCHEMBL2649908;DTXSID60469831;JVHNKZBMDNRVRP-UHFFFAOYSA-N;4-fluoro-3-(3,5-difluoropyridin-2-yl)phenylboronic acid

Suppliers and Price of (3-(3,5-Difluoropyridin-2-yl)-4-fluorophenyl)boronic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (3-(3,5-Difluoropyridin-2-yl)-4-fluorophenyl)boronic acid

Chemical Property:

Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:253.0521931
Heavy Atom Count:18
Complexity:285

Purity/Quality:: 95%-98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:B(C1=CC(=C(C=C1)F)C2=C(C=C(C=N2)F)F)(O)O

Technology Process of (3-(3,5-Difluoropyridin-2-yl)-4-fluorophenyl)boronic acid

There total 4 articles about (3-(3,5-Difluoropyridin-2-yl)-4-fluorophenyl)boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 425379-31-3
2-(5-bromo-2-fluorophenyl)-3,5-difluoropyridine

: 425379-32-4
[3-(3,5-difluoropyridin-2-yl)-4-fluorophenyl]boronic acid

Guidance literature:: 2-(5-bromo-2-fluorophenyl)-3,5-difluoropyridine; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane; In 1,4-dioxane; dichloromethane; at 80 ℃; for 24h;

With hydrogenchloride; at 40 ℃; for 0.5h;
DOI:10.1021/jm051144x

Reference yield:

: 660425-16-1
2-bromo-3,5-difluoropyridine

: 425379-32-4
[3-(3,5-difluoropyridin-2-yl)-4-fluorophenyl]boronic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 90 percent / potassium fluoride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butylphosphine / tetrahydrofuran; H₂O; hexane / 24 h / 55 °C

2.1: 70 percent / dibromodimethylhydantoin; sulfuric acid / acetonitrile / 2 h / 55 °C

3.1: bis(neopentylglycolato)diboron; potassium acetate; dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) / dioxane; CH₂Cl₂ / 24 h / 80 °C

3.2: 97 percent / aq. HCl / 0.5 h / 40 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; tri-tert-butyl phosphine; sulfuric acid; potassium acetate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; acetonitrile; 1.1: Suzuki coupling;
DOI:10.1021/jm051144x

Reference yield:

: 884863-46-1
3,5-difluoro-2-(2-fluorophenyl)pyridine

: 425379-32-4
[3-(3,5-difluoropyridin-2-yl)-4-fluorophenyl]boronic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 70 percent / dibromodimethylhydantoin; sulfuric acid / acetonitrile / 2 h / 55 °C

2.1: bis(neopentylglycolato)diboron; potassium acetate; dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) / dioxane; CH₂Cl₂ / 24 h / 80 °C

2.2: 97 percent / aq. HCl / 0.5 h / 40 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid; potassium acetate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane; In 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1021/jm051144x