4-(chloromethyl)-N,N-dimethylaniline

Base Information

• Chemical Name: 4-(chloromethyl)-N,N-dimethylaniline
• CAS No.: 42600-58-8
• Molecular Formula: C9H12ClN
• Molecular Weight: 169.654
• Mol file: 42600-58-8.mol

Synonyms:p-(chloromethyl)-N,N-dimethylaniline;4-chloromethyl-N,N-dimethyl-aniline;4-Chlormethyl-N,N-dimethyl-anilin;11-Chlor-4-dimethylamino-toluol;4-N,N-dimethyl benzyl chloride;4-Dimethylamino-benzylchlorid;

Chemical Property of 4-(chloromethyl)-N,N-dimethylaniline

Chemical Property:

• PSA: 3.24000
• LogP: 2.49140

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(chloromethyl)-N,N-dimethylaniline

There total 7 articles about 4-(chloromethyl)-N,N-dimethylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N,N-dimethyl-4-hydroxymethylaniline (1703-46-4) → 4-(dimethylamino)-1-(chloromethyl)-benzene (42600-58-8)

Guidance literature:

With thionyl chloride; for 5h; Cooling with ice;

Reference yield: 67.0%

4-dimethylaminobenzyl Co(III)(dmgH)2py (113149-79-4) → ((CH3)2N)2ClC6H4CH2(1-)*Co(3+)*C5H5N*2(C4H7N2O2)(1-)=Co{((CH3)2N)2ClC6H4CH2}(C5H5N)(C4H7N2O2)2 (113173-12-9) + 4-(dimethylamino)-1-(chloromethyl)-benzene (42600-58-8)

Guidance literature:

With chlorine; In acetic acid; a solution of one equivalent of halogen added dropwise to a solution of organocobaloxime at room temperature under nitrogen in the dark; NMR, UV;

Reference yield: 67.0%

substituted benzylcobaloxime + chlorine (7782-50-5) → ((CH3)2C2N2OOH)2*Co*(C5H5N)*C6H3CH2ClN(CH3)2=((CH3)2C2N2OOH)2CoCH2C6H3ClN(CH3)2(C5H5N) + 4-(dimethylamino)-1-(chloromethyl)-benzene (42600-58-8)

Guidance literature:

In chloroform; reaction of solutions of starting materials in dry chloroform under N2 at room temp. (one mole of halogen is used);

DOI:10.1246/cl.1987.701

upstream raw materials:

4-dimethylaminobenzyl Co(III)(dmgH)2py

chlorine

dichloromethane

p-(dimethylamino)phenyl azide

Downstream raw materials:

N,N-dimethyl-4-(methylsulfanyl-methyl)-aniline

N,N-dimethyl-4-phenoxymethyl-aniline

N,N-dimethyl-4-((phenylthio)methyl)aniline

4-benzenesulfonylmethyl-N,N-dimethyl-aniline