2-Chloro-4-methoxyquinoline

Base Information

• Chemical Name: 2-Chloro-4-methoxyquinoline
• CAS No.: 4295-09-4
• Molecular Formula: C10H8ClNO
• Molecular Weight: 193.633
• Hs Code.: 2933499090
• European Community (EC) Number: 898-458-7
• ChEMBL ID: CHEMBL193905
• DSSTox Substance ID: DTXSID40494722
• Wikidata: Q82342306
• Mol file: 4295-09-4.mol

Synonyms:2-Chloro-4-methoxyquinoline;4295-09-4;2-Chloro-4-methoxy-quinoline;CHEMBL193905;SCHEMBL2539705;DTXSID40494722;LVWGQKSYKDQZKF-UHFFFAOYSA-N;MFCD10000786;AKOS006302854;AB55891;AS-43141;CS-0169576;EN300-6222117

Chemical Property of 2-Chloro-4-methoxyquinoline

Chemical Property:

• PSA: 22.12000
• LogP: 2.89680
• Storage Temp.: 2-8°C
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 193.0294416
• Heavy Atom Count: 13
• Complexity: 176

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-4-methoxy-quinoline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=NC2=CC=CC=C21)Cl

Technology Process of 2-Chloro-4-methoxyquinoline

There total 1 articles about 2-Chloro-4-methoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dichloroquinoline (703-61-7) → 2-chloro-4-methoxy quinoline (4295-09-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium methylate / 5 h / Heating

2: hydrogenchloride; acetic acid / 4 h / Reflux

3: trichlorophosphate / 4 h / Reflux

With hydrogenchloride; sodium methylate; acetic acid; trichlorophosphate;

Reference yield: 82.0%

2-(4-Fluoro-3-trifluoromethyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (445303-14-0) + 2-chloro-4-methoxy quinoline (4295-09-4) → hydrogen 2-(4-fluoro-3-trifluoromethylphenyl)-4-methoxyquinoline

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In methanol; toluene; at 85 ℃; Inert atmosphere; Reflux;

Reference yield: 49.0%

2-chloro-4-methoxy quinoline (4295-09-4) + (S,S)-1,2-diphenyl-1,2-diaminoethane (29841-69-8) → C34H30N4O2

Guidance literature:

With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium⁽⁰⁾; sodium t-butanolate; In toluene; at 80 ℃; for 1.5h; Inert atmosphere;

DOI:10.1021/ol503626w

upstream raw materials:

2,4-dichloroquinoline

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