1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[1-[4-[(cyclopentylamino)carbonyl]-2-thiazolyl]-3-azetidinyl]thio]-6-[(1R )-1-hydroxyethyl]-4-methyl-7-oxo-, (4-nitrophenyl)methyl ester, (4R,5S,6S)-

Base Information

Chemical Name:1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[1-[4-[(cyclopentylamino)carbonyl]-2-thiazolyl]-3-azetidinyl]thio]-6-[(1R )-1-hydroxyethyl]-4-methyl-7-oxo-, (4-nitrophenyl)methyl ester, (4R,5S,6S)-
CAS No.:429664-97-1
Molecular Formula:C29H33N5O7S2
Molecular Weight:627.742
Hs Code.:
Mol file:429664-97-1.mol

1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid,
3-[[1-[4-[(cyclopentylamino)carbonyl]-2-thiazolyl]-3-azetidinyl]thio]-6-[(1R
)-1-hydroxyethyl]-4-methyl-7-oxo-, (4-nitrophenyl)methyl ester,
(4R,5S,6S)-

Synonyms:

Suppliers and Price of 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[1-[4-[(cyclopentylamino)carbonyl]-2-thiazolyl]-3-azetidinyl]thio]-6-[(1R )-1-hydroxyethyl]-4-methyl-7-oxo-, (4-nitrophenyl)methyl ester, (4R,5S,6S)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[1-[4-[(cyclopentylamino)carbonyl]-2-thiazolyl]-3-azetidinyl]thio]-6-[(1R )-1-hydroxyethyl]-4-methyl-7-oxo-, (4-nitrophenyl)methyl ester, (4R,5S,6S)-

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Technology Process of 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[1-[4-[(cyclopentylamino)carbonyl]-2-thiazolyl]-3-azetidinyl]thio]-6-[(1R )-1-hydroxyethyl]-4-methyl-7-oxo-, (4-nitrophenyl)methyl ester, (4R,5S,6S)-

There total 4 articles about 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[1-[4-[(cyclopentylamino)carbonyl]-2-thiazolyl]-3-azetidinyl]thio]-6-[(1R )-1-hydroxyethyl]-4-methyl-7-oxo-, (4-nitrophenyl)methyl ester, (4R,5S,6S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 429667-10-7
3-acetylthio-1-(4-N-cyclopentylcarbamoyl-1,3-thiazol-2-yl)azetidine

: 93711-81-0,90776-59-3,189188-38-3
(4-nitrophenyl)methyl (4R,5R,6S)-3-[(diphenoxyphosphinyl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

: 429664-97-1
p-nitrobenzyl (1R,5S,6S)-2-[1-(4-N-cyclopentylcarbamoyl-1,3-thiazol-2-yl)azetidin-3-yl]thio-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate

Guidance literature:: 3-acetylthio-1-(4-N-cyclopentylcarbamoyl-1,3-thiazol-2-yl)azetidine; With hydrazinium monoacetate; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 1h;

(4-nitrophenyl)methyl (4R,5R,6S)-3-[(diphenoxyphosphinyl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate; With N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); acetonitrile; at 0 - 20 ℃;

With sodium hydrogencarbonate; In DMF (N,N-dimethyl-formamide); water; ethyl acetate; acetonitrile;

Reference yield: 33.0%

: 429667-10-7
3-acetylthio-1-(4-N-cyclopentylcarbamoyl-1,3-thiazol-2-yl)azetidine

: 144-55-8
sodium hydrogencarbonate

: 93711-81-0,90776-59-3,189188-38-3
(4-nitrophenyl)methyl (4R,5R,6S)-3-[(diphenoxyphosphinyl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

: 429664-97-1
p-nitrobenzyl (1R,5S,6S)-2-[1-(4-N-cyclopentylcarbamoyl-1,3-thiazol-2-yl)azetidin-3-yl]thio-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate

Guidance literature:: With hydrazinium monoacetate; N-ethyl-N,N-diisopropylamine; In N-methyl-acetamide; ethyl acetate; acetonitrile;

Reference yield:

: 429667-16-3
1-(4-N-cyclopentylcarbamoyl-1,3-thiazol-2-yl)-3-methanesulfonyloxyazetidine

: 429664-97-1
p-nitrobenzyl (1R,5S,6S)-2-[1-(4-N-cyclopentylcarbamoyl-1,3-thiazol-2-yl)azetidin-3-yl]thio-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-methyl-acetamide

2: hydrazinium monoacetate; N-ethyl-N,N-diisopropylamine / N-methyl-acetamide; ethyl acetate; acetonitrile

With hydrazinium monoacetate; N-ethyl-N,N-diisopropylamine; In N-methyl-acetamide; ethyl acetate; acetonitrile;