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Sodium bicarbonate

Base Information Edit
  • Chemical Name:Sodium bicarbonate
  • CAS No.:144-55-8
  • Molecular Formula:NaHCO3
  • Molecular Weight:84.0069
  • Hs Code.:28363000
  • Mol file:144-55-8.mol
Sodium bicarbonate

Synonyms:Carbonic acid, monosodium salt;Natriumhydrogenkarbonat;Meylon;Carbonic acid disodium salt;SodaSee;Monosodium hydrogen carbonate;Monosodium carbonate;monosodium salt ;; see the subdivided heading;Component of Col-Evac;Soda Mint;Sodium bicarbonate(1:1);Carbonic acid, disodium salt;Natriumbicarbonat, Natriumhydrogencarbonat;Sodium Bicarbonate food grade;

Suppliers and Price of Sodium bicarbonate
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Chem-Impex
  • Sodium bicarbonate 99.0 - 100.5% (Assay by titration anhydrous basis)
  • 1KG
  • $ 15.00
  • Chem-Impex
  • Sodiumbicarbonate,99.0-100.3%(Assaybytitration,driedbasis),ACSreagent 99.0-100.3%(Assaybytitration,driedbasis)
  • 1KG
  • $ 23.30
  • Chem-Impex
  • Sodiumbicarbonate,99.0-100.5%(Assaybytitrationanhydrousbasis),meetsUSPspecifications 99.0-100.5%(Assaybytitrationanhydrousbasis)
  • 2.5KG
  • $ 29.12
  • Chem-Impex
  • Sodium bicarbonate 99.0 -100.3% (Assay by titration, dried basis)
  • 2.5KG
  • $ 40.00
  • Chem-Impex
  • Sodium bicarbonate 99.0 - 100.5% (Assay by titration anhydrous basis)
  • 5KG
  • $ 45.00
  • Chem-Impex
  • Sodium bicarbonate 99.0 - 100.5% (Assay by titration anhydrous basis)
  • 250KG
  • $ 1290.00
  • Chem-Impex
  • Sodium bicarbonate 99.0 -100.3% (Assay by titration, dried basis)
  • 100KG
  • $ 890.00
  • Chem-Impex
  • Sodium bicarbonate 99.0 - 100.5% (Assay by titration anhydrous basis)
  • 100KG
  • $ 570.00
  • Chem-Impex
  • Sodium bicarbonate 99.0 -100.3% (Assay by titration, dried basis)
  • 25KG
  • $ 240.00
  • Chem-Impex
  • Sodiumbicarbonate,99.0-100.5%(Assaybytitrationanhydrousbasis),meetsUSPspecifications 99.0-100.5%(Assaybytitrationanhydrousbasis)
  • 25KG
  • $ 180.54
Total 700 raw suppliers
Chemical Property of Sodium bicarbonate Edit
Chemical Property:
  • Appearance/Colour:white powder or crystals 
  • Vapor Pressure:2.58E-05mmHg at 25°C 
  • Melting Point:50 °C, 323 K, 122 °F (decomposes) 
  • Refractive Index:1.500 
  • Boiling Point:333.6 °C at 760 mmHg 
  • PKA:(1) 6.37, (2) 10.25 (carbonic (at 25℃) 
  • Flash Point:169.8 °C 
  • PSA:60.36000 
  • Density:2.173 g/cm3 
  • LogP:-1.11230 
  • Storage Temp.:2-8°C 
  • Solubility.:H2O: 1 M at 20 °C, clear, colorless 
  • Water Solubility.:9 g/100 mL (20 ºC) 
Purity/Quality:

99.5% *data from raw suppliers

Sodium bicarbonate 99.0 - 100.5% (Assay by titration anhydrous basis) *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
  • Safety Statements: 24/25 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Historical Research Research on the effects of sodium bicarbonate on exercise performance dates back to the 1930s. Early studies demonstrated improved performance with pre-exercise alkalosis induced by sodium bicarbonate ingestion. Notably, a landmark study in 1977 by Jones et al. showed that participants cycled significantly longer to exhaustion after ingesting sodium bicarbonate compared to control conditions.
  • Industrial Applications Sodium bicarbonate is used in various industrial sectors, including chemical, food, textile, and pharmaceutical industries. Its production from CO2 capture and reuse has gained importance due to environmental concerns. Raw materials like sodium chloride, sodium carbonate, and sodium sulfate are commonly used in its production process.
  • Medical Uses Sodium bicarbonate serves as an antacid for relieving heartburn and acid indigestion. Additionally, it is employed in prescription and over-the-counter medications for various purposes.
  • Ergogenic Aid Studies have explored the effects of sodium bicarbonate on exercise performance across different modes of exercise, including combat sports, resistance exercise, and high-intensity cycling, running, swimming, and rowing. Sodium bicarbonate is used as an ergogenic aid in these contexts.
  • Solubility and Dissociation Sodium bicarbonate is highly soluble in water, dissociating promptly into sodium (Na+) and bicarbonate (HCO3-) ions upon contact with aqueous solutions, such as stomach acid. This dissociation process contributes to its physiological effects.
  • Physiological Effects Upon ingestion, sodium bicarbonate reacts with stomach acid, leading to the formation of carbon dioxide (CO2), which is then released from the gastric juice through belching. Despite some bicarbonate being neutralized by stomach acid, it alkalizes gastric juice, stimulating bicarbonate transport into the blood through cellular mechanisms.
  • Dosage and Timing Studies typically use a dose of 0.3 g/kg of body weight of sodium bicarbonate, administered approximately 3 hours before exercise. This dosage and timing have become standard in research examining the effects of sodium bicarbonate on exercise performance.
  • Significance in Exercise Physiology Research on sodium bicarbonate's effects on exercise performance has had a significant impact on the field of exercise physiology, contributing to our understanding of buffering capacity, acid-base balance, and strategies for enhancing athletic performance.
Technology Process of Sodium bicarbonate

There total 170 articles about Sodium bicarbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
In methanol; after N. A. Gol'dberg and V. G. Golov, Zh. Prikl. Khim., 35, 2106 (1962);
Guidance literature:
With carbon dioxide; triphenylphosphine; In acetonitrile; Irradiation (UV/VIS); (Ar or N2); UV irradn. (>420 nm) of soln. of W compd. and PPh3 with stirring at ca. 20°C for ca. 12 h under CO2 pressure, formed ppt. was sepd.; W compds. were detected IR spect. in filtrate, not isolated; NaHCOO detected 1HNMR spect. in D2O soln. of ppt.; Na2CO3 and NaHCO3 detd. in aq. soln. of ppt. by titrn.;
Guidance literature:
In water; equilibrium reaction;;
Refernces Edit

C-F activation reactions of (pentafluorophenyl)cyclopentadiene and 3-(pentafluorophenyl)indene with tetrakis(dimethylamido)titanium(IV)

10.1021/om034385g

The study investigates the reactions of 3-(pentafluorophenyl)indene and (pentafluorophenyl)cyclopentadiene with tetrakis(dimethylamido)titanium(IV), resulting in the formation of products where one or both ortho fluorines of the C6F5 group are replaced by dimethylamino groups. This suggests a titanium-mediated, intramolecular nucleophilic aromatic substitution mechanism. The research led to the isolation of organic products and the conversion of substituted cyclopentadiene to a ferrocene derivative. The study provides insights into the selective activation of polyfluorinated organic compounds, a significant challenge in synthetic chemistry, and contributes to the understanding of transition metal complex mechanisms for C-F activation.

Generation of a small library of highly electron-rich 2-(hetero)aryl- substituted phenethylamines by the Suzuki-Miyaura reaction: A short synthesis of an apogalanthamine analogue

10.1002/ejoc.200400213

The research focuses on the synthesis of a small library of highly electron-rich 2-aryl and 2-heteroaryl phenethylamines (PEAs) using the Suzuki-Miyaura cross-coupling reaction, which is enhanced by microwave irradiation for improved reaction yield and speed. The study commenced with the synthesis of benzyl [2-(2-bromo-4,5-dimethoxyphenyl)ethyl]carbamate from 2-(3,4-dimethoxyphenyl)ethylamine, followed by its coupling with various boronic acids to generate the PEAs. The reactions were optimized using sodium hydrogencarbonate as the base and tetrakis(triphenylphosphane)palladium(0) as the catalyst, with the mixture of N,N-dimethylformamide and water as the solvent. The synthesized compounds were characterized by 1H and 13C NMR spectroscopy, and low-resolution mass spectrometry (LR-MS) to confirm their structures and purities. The research also successfully extended this methodology to synthesize an apogalanthamine analogue, a complex natural product with significant biological activities, showcasing the versatility and efficacy of the developed synthetic strategy.

Copper-catalyzed highly efficient multicomponent reactions of terminal alkynes, acid chlorides, and carbodiimides: synthesis of functionalized propiolamidine derivatives

10.1002/adsc.200700333

The research focuses on the copper-catalyzed multicomponent reactions (MCRs) of terminal alkynes, acid chlorides, and carbodiimides to synthesize functionalized propiolamidine derivatives. The study explores the efficiency of various bases and solvents to optimize the reaction conditions. The optimal catalytic system was found to be a combination of CuI, triethylamine (TEA), and acetonitrile (CH3CN), yielding the desired products in good to excellent yields. The experiments involved a suspension of carbodiimide and acid chloride, followed by the addition of anhydrous acetonitrile, TEA, CuI, and alkyne at room temperature under a nitrogen atmosphere. The reaction mixture was stirred, then extracted with CH2Cl2, washed with saturated NaHCO3 solution and water, dried over anhydrous MgSO4, and evaporated under vacuum. The residue was purified using silica gel column chromatography with petroleum ether/ethyl acetate as the eluent. The analysis of the reaction products was based on isolated yields, which were calculated based on the amount of N,N’-dialkylcarbodiimides used.

Synthesis of Imidazo[1,2-a]pyridines and Imidazo[2,1-b]thiazoles Attached to a Cycloalkyl or Saturated Heterocycle Containing a Tertiary Hydroxy Substitution

10.1002/jhet.3454

The research focuses on the synthesis of imidazo[1,2-a]pyridines and imidazo[2,1-b]thiazoles with tertiary hydroxy substitutions, utilizing readily available substituted 2-aminopyridines, 2-aminothiazoles, and 2-aminobenzothiazoles. The experiments involved treating these amines with bromohydroxycycloalkyl ethanones under various reaction conditions to optimize yields, with sodium bicarbonate as the base in 1,4-dioxane at elevated temperatures yielding the best results. The reactants included substituted acylbromides and different amino compounds, while the analyses employed included NMR spectroscopy for structural confirmation and high-resolution mass spectrometry for molecular weight determination. The study successfully demonstrated a more efficient synthetic route for these compounds, filling gaps in existing literature on related structures.

Improved Procedure for Preparation of t-Alkyl Aryl Ethers

10.1055/s-1982-29739

The research aimed to improve the procedure for the preparation of t-alkyl aryl ethers, which are compounds for which synthesis methods in the literature are scarce and complex. The main challenge in synthesizing these compounds is the occurrence of side reactions, such as elimination reactions of the starting r-alkyl halide in basic media or rearrangements of the final product to C-alkylated phenols under acid conditions. The researchers reported a convenient modification of the existing procedure using nickel bisacetylacetonate as a catalyst and sodium hydrogen carbonate as a hydrogen chloride acceptor. This method was applied to various phenols and r-alkyl chlorides to produce t-alkyl aryl ethers with yields and conversions summarized in a table. The study concluded that the procedure was not effective for phenols with strong electron-withdrawing substituents and that ortho-substituted phenols reacted sluggishly, leading to variable amounts of rearranged products. The chemicals used in the process included phenols, r-alkyl chlorides, nickel acetylacetonate, sodium hydrogen carbonate, and diethyl ether, among others.

C(10)-C(19) bond cleavage reaction of 19-oxygenated androst-4-ene-3,6-dione steroids under various conditions

10.1248/cpb.52.983

This research investigates the C(10)–C(19) bond cleavage reaction of 19-oxygenated androst-4-ene-3,6-dione steroids under various conditions, with the aim of understanding the effect of introducing a carbonyl group at C-6 on these reactions in relation to biological aromatization. The study explores the reactions of 19-oxygenated 6-oxo steroids 5 and 6 under both basic and acidic conditions, using chemicals such as KOH, NaHCO3, CH3COSK, HCl, and pyridine. The conclusions drawn from the research indicate that the introduction of the C6 carbonyl group into 19-hydroxy and 19-oxo steroids accelerates and/or triggers C(10)–C(19) bond cleavage reactions under both acidic and basic conditions, leading to unique outcomes for 6-oxosteroids 5 and 6.

PREPARATION OF CYCLIC ETHER ACETALS FROM 2-BENZENESULPHONYL DERIVATIVES: A NEW MILD GLYCOSIDATION PROCEDURE

10.1016/S0040-4039(00)80631-0

The research aims to develop a mild and efficient method for the formation of cyclic ether acetals using 2-benzenesulphonyl derivatives. The study explores the reaction of various alcohols, including those with chemically sensitive groups and sterically hindered substrates, with 2-benzenesulphonyl cyclic ethers in the presence of magnesium bromide etherate and sodium bicarbonate. This approach is particularly significant as it provides a mild alternative to traditional acidic methods for introducing protecting groups like tetrahydropyranyl. The researchers found that a wide range of alcohols reacted well under these conditions, yielding high-quality acetals without affecting other functional groups such as furan rings, silyl-protected alcohols, double and triple bonds, acetals, and carbonyl groups. The study also briefly investigated the extension of this method to glycoside bond formation, demonstrating its potential for natural product synthesis and applications involving sensitive functional groups. Key chemicals used in the research include 2-benzenesulphonyl cyclic ethers, alcohols, magnesium bromide etherate, sodium bicarbonate, and tetrahydrofuran as the solvent. The findings suggest that this mild acetalation procedure could be a valuable tool in organic synthesis, especially in contexts where functional group compatibility is crucial.

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