4-Thiazolecarboxylic acid, 2-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-piperidinyl]-, (4-nitrophenyl)methyl ester

Base Information

Chemical Name:4-Thiazolecarboxylic acid, 2-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-piperidinyl]-, (4-nitrophenyl)methyl ester
CAS No.:429667-55-0
Molecular Formula:C22H31N3O5SSi
Molecular Weight:477.657
Hs Code.:
Mol file:429667-55-0.mol

Synonyms:

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Chemical Property of 4-Thiazolecarboxylic acid, 2-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-piperidinyl]-, (4-nitrophenyl)methyl ester

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Technology Process of 4-Thiazolecarboxylic acid, 2-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-piperidinyl]-, (4-nitrophenyl)methyl ester

There total 2 articles about 4-Thiazolecarboxylic acid, 2-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-piperidinyl]-, (4-nitrophenyl)methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 429667-53-8
4-t-butyldimethylsilyloxy-1-(4-carboxyl-1,3-thiazol-2-yl)piperidine

: 619-73-8
4-nitrobenzyl chloride

: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (WSC)

: 2592-95-2
benzotriazol-1-ol

: 429667-55-0
4-t-butyldimethylsilyloxy-1-(4-p-nitrobenzyloxycarbonyl-1,3-thiazol-2-yl)piperidine

Guidance literature:: In dichloromethane;

Reference yield:

: 4-t-butyldimethylsilyloxy-1-(4-ethoxycarbonyl-1,3-thiazol-2-yl)piperidine

: 429667-55-0
4-t-butyldimethylsilyloxy-1-(4-p-nitrobenzyloxycarbonyl-1,3-thiazol-2-yl)piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; sodium hydroxide / methanol; ethanol; ethyl acetate

2: dichloromethane

With hydrogenchloride; sodium hydroxide; In methanol; ethanol; dichloromethane; ethyl acetate;

Reference yield: 54.0%

: 429667-55-0
4-t-butyldimethylsilyloxy-1-(4-p-nitrobenzyloxycarbonyl-1,3-thiazol-2-yl)piperidine

: 1-(4-p-nitrobenzyloxycarbonyl-1,3-thiazol-2-yl)-4-hydroxypiperidine

Guidance literature:: 4-t-butyldimethylsilyloxy-1-(4-p-nitrobenzyloxycarbonyl-1,3-thiazol-2-yl)piperidine; With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 0 - 20 ℃; for 21h;

With sodium hydrogencarbonate; In tetrahydrofuran; water; ethyl acetate;