4-methanesulfonyloxy-1-(4-p-nitrobenzyloxycarbonyl-1,3-thiazol-2-yl)piperidine

Base Information

Chemical Name:4-methanesulfonyloxy-1-(4-p-nitrobenzyloxycarbonyl-1,3-thiazol-2-yl)piperidine
CAS No.:429667-58-3
Molecular Formula:C₁₇H₁₉N₃O₇S₂
Molecular Weight:441.486
Hs Code.:

Synonyms:4-methanesulfonyloxy-1-(4-p-nitrobenzyloxycarbonyl-1,3-thiazol-2-yl)piperidine

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Chemical Property of 4-methanesulfonyloxy-1-(4-p-nitrobenzyloxycarbonyl-1,3-thiazol-2-yl)piperidine

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Technology Process of 4-methanesulfonyloxy-1-(4-p-nitrobenzyloxycarbonyl-1,3-thiazol-2-yl)piperidine

There total 5 articles about 4-methanesulfonyloxy-1-(4-p-nitrobenzyloxycarbonyl-1,3-thiazol-2-yl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1-(4-p-nitrobenzyloxycarbonyl-1,3-thiazol-2-yl)-4-hydroxypiperidine

: 124-63-0
methanesulfonyl chloride

: 429667-58-3
4-methanesulfonyloxy-1-(4-p-nitrobenzyloxycarbonyl-1,3-thiazol-2-yl)piperidine

Guidance literature:: 1-(4-p-nitrobenzyloxycarbonyl-1,3-thiazol-2-yl)-4-hydroxypiperidine; methanesulfonyl chloride; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1.16667h;

With sodium hydrogencarbonate; In dichloromethane; water; ethyl acetate;

Reference yield:

: 429667-53-8
4-t-butyldimethylsilyloxy-1-(4-carboxyl-1,3-thiazol-2-yl)piperidine

: 429667-58-3
4-methanesulfonyloxy-1-(4-p-nitrobenzyloxycarbonyl-1,3-thiazol-2-yl)piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane

2: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran

3: triethylamine / dichloromethane

With tetrabutyl ammonium fluoride; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 4-t-butyldimethylsilyloxy-1-(4-ethoxycarbonyl-1,3-thiazol-2-yl)piperidine

: 429667-58-3
4-methanesulfonyloxy-1-(4-p-nitrobenzyloxycarbonyl-1,3-thiazol-2-yl)piperidine

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; sodium hydroxide / methanol; ethanol; ethyl acetate

2: dichloromethane

3: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran

4: triethylamine / dichloromethane

With hydrogenchloride; sodium hydroxide; tetrabutyl ammonium fluoride; acetic acid; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate;