Methyl (R)-Piperidine-2-Carboxylate

Base Information

• Chemical Name: Methyl (R)-Piperidine-2-Carboxylate
• CAS No.: 43041-11-8
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 143.186
• Hs Code.: 2933998087
• Mol file: 43041-11-8.mol

Synonyms:(S)-pipecolic acid,methyl ester;D/L Pip-OMe;Methyl 2-piperidinecarboxylate;Piperidine-2-carboxylic acid methyl ester;methyl L-piperidine-2-carboxylate;2-Carbomethoxy piperidine;2-Piperidinecarboxylic acid methyl ester;L-pipecolic acid methyl ester;methyl pipecolinate;

Chemical Property of Methyl (R)-Piperidine-2-Carboxylate

Chemical Property:

• Vapor Pressure: 0.457mmHg at 25°C
• Boiling Point: 193.8oC at 760 mmHg
• PKA: 8.27±0.10(Predicted)
• Flash Point: 71oC
• PSA: 38.33000
• Density: 1.021g/cm3
• LogP: 0.63030
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl(R)-Piperidine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl (R)-Piperidine-2-carboxylate was used as a reactant in the discovery of a selective EP4 receptor antagonist and analgesic.

Technology Process of Methyl (R)-Piperidine-2-Carboxylate

There total 55 articles about Methyl (R)-Piperidine-2-Carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methanol (67-56-1) + pipecolic Acid (4043-87-2,83680-83-5) → methyl pipecolinate (35677-83-9,41994-45-0,43041-11-8,90710-04-6)

Guidance literature:

With thionyl chloride; at 20 ℃; for 48h;

DOI:10.1021/jm0500830

Reference yield: 92.0%

methanol (67-56-1) + (R)-(+)-pipecolic acid (1723-00-8,83680-83-5) → (+)-2R-Piperidine-2-carboxylic acid methyl ester (35677-83-9,41994-45-0,43041-11-8,90710-04-6)

Guidance literature:

With thionyl chloride; In 0 - 20C; Inert atmosphere;

Reference yield: 92.0%

methyl 1-tritylpiperidine-2-carboxylate (1262670-70-1) → methyl pipecolinate (35677-83-9,41994-45-0,43041-11-8,90710-04-6)

Guidance literature:

With ammonium cerium (IV) nitrate; water; acetic acid; In dichloromethane; at 20 ℃; for 0.75h; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.10.118

upstream raw materials:

(R)-(+)-pipecolic acid

(R)-2-[(1S,2S,5S)-2-Hydroxy-2,6,6-trimethyl-bicyclo[3.1.1]hept-(3Z)-ylideneamino]-6-iodo-hexanoic acid methyl ester

(R)-1-((S)-1-Phenyl-ethyl)-piperidine-2-carboxylic acid methyl ester

N-(2-methoxy-6-methylphenyl)pipecolic acid methyl ester

Downstream raw materials:

(2R)-piperidin-2-ylmethanol

(R)-(+)-pipecolic acid

(+)-2R-Piperidine-2-carboxylic acid amide

(+/-) methyl N-tert-butyloxycarbonyl 2-piperidinecarboxylate

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