Ethyl 7-chloroindole-2-carboxylate

Base Information

• Chemical Name: Ethyl 7-chloroindole-2-carboxylate
• CAS No.: 43142-64-9
• Molecular Formula: C11H10ClNO2
• Molecular Weight: 223.659
• Mol file: 43142-64-9.mol

Synonyms:ethyl 7-chloro-2-indolecarboxylate;ethyl 7-chloro-1H-indole-2-carboxylate;7-chloro-1H-indole-2-carboxylic acid ethyl ester;7-chloro-indole-2-carboxylic acid ethyl ester;7-Chlor-indol-2-carbonsaeure-aethylester;Ethyl 7-chloroindole-2-carboxylate;

Chemical Property of Ethyl 7-chloroindole-2-carboxylate

Chemical Property:

• Melting Point: 113.5 - 114 °C
• Boiling Point: 375.0±22.0 °C(Predicted)
• PKA: 13.43±0.30(Predicted)
• PSA: 42.09000
• Density: 1.329±0.06 g/cm3(Predicted)
• LogP: 2.99800
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Ethyl7-chloro-1H-indole-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethyl 7-chloroindole-2-carboxylate

There total 2 articles about Ethyl 7-chloroindole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

(Z)-ethyl α-azido-β-(m-chlorophenyl)acrylate (1458040-73-7) → 7-Chloro-1H-indole-2-carboxylic acid ethyl ester (43142-64-9) + 5-chloro-indole-2-carboxylic acid ethyl ester (4792-67-0)

Guidance literature:

In 1,2-dichloro-benzene; at 150 ℃; for 0.5h; regioselective reaction;

DOI:10.1039/c3ra42296h

Reference yield: 31.0%

C11H10ClN3O2 (368889-92-3) → 7-Chloro-1H-indole-2-carboxylic acid ethyl ester (43142-64-9) + 5-chloro-indole-2-carboxylic acid ethyl ester (4792-67-0)

Guidance literature:

With zirconium(IV) chloride; silver nitrate; In 1,2-dichloro-ethane; at 0 - 20 ℃; for 0.166667h; Overall yield = 61 %;

DOI:10.1039/c4ra02158d

Reference yield: 100.0%

7-Chloro-1H-indole-2-carboxylic acid ethyl ester (43142-64-9) → 7-Chloro-1H-indole-2-carboxylic acid (28899-75-4)

Guidance literature:

With lithium hydroxide; In ethanol; water; at 20 ℃; for 18h;

DOI:10.1021/jm0341047

upstream raw materials:

(Z)-ethyl α-azido-β-(m-chlorophenyl)acrylate

C₁₁H₁₀ClN₃O₂

Downstream raw materials:

7-Chloro-1H-indole-2-carboxylic acid

Ethyl 1-benzyl-7-chloroindole-2-carboxylate

3-(2-Amino-phenylamino)-7-chloro-1H-indole-2-carboxylic acid ethyl ester

(7-Chloro-3-p-tolylamino-1H-indol-2-yl)-carbamic acid ethyl ester

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