28899-75-4

Basic information

• Product Name: 7-chloro-1H-indole-2-carboxylic acid
• Synonyms: 7-chloro-1H-indole-2-carboxylic acid(SALTDATA: FREE);7-Chloroindole-2-carboxylic acid;1H-Indole-2-carboxylic acid, 7-chloro-
• CAS NO: 28899-75-4
• Molecular Formula: C₉H₆ClNO₂
• Molecular Weight: 195.61
• EINECS: 249-296-5
• Mol File: 28899-75-4.mol

Chemical Properties

• Boiling Point: 449.7°Cat760mmHg
• Flash Point: 225.8°C
• Appearance: /
• Density: 1.548g/cm³
• Vapor Pressure: 7.12E-09mmHg at 25°C
• Refractive Index: 1.728
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.23±0.30(Predicted)
• CAS DataBase Reference: 7-chloro-1H-indole-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 7-chloro-1H-indole-2-carboxylic acid(28899-75-4)
• EPA Substance Registry System: 7-chloro-1H-indole-2-carboxylic acid(28899-75-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 28899-75-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
7-chloro-1H-indole-2-carboxylic acid is used as a pharmaceutical intermediate for the synthesis of various indole-containing compounds. Its unique structure allows it to serve as a building block in the development of new drugs.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 7-chloro-1H-indole-2-carboxylic acid is used as a subject of study for its potential biological activities. It has been investigated for its anti-inflammatory and antiproliferative effects, making it a promising candidate for the development of therapeutic agents.
Used in Chemical Compounds Industry:
7-chloro-1H-indole-2-carboxylic acid is used as a chemical compound in the production of other indole-containing compounds, contributing to the diversity of chemical products available for various applications.

InChI:InChI=1/C9H6ClNO2/c10-6-3-1-2-5-4-7(9(12)13)11-8(5)6/h1-4,11H,(H,12,13)

Upstream product

• 77158-85-1 (3-chloro-2-nitro-phenyl)-pyruvic acid 
• 115050-49-2 ethyl 2-[2-(2-chlorophenyl)hydrazinylidene]propanoate 
• 41052-75-9 o-chlorophenylhydrazine hydrochloride 
• 43142-70-7 ethyl (E)-2-(2-(2-chlorophenyl)hydrazono)propanoate 
• 43142-64-9 7-Chloro-1H-indole-2-carboxylic acid ethyl ester 

Downstream Products

• 53924-05-3 7-chloro-1H-indole 
• 1670-83-3 1H-Indole-7-carboxylic acid 
• 1473450-48-4 7-chloro-N-(cis-4-methylcyclohexyl)-1H-indole-2-carboxamide 
• 1473450-49-5 7-chloro-N-(trans-4-methylcyclohexyl)-1H-indole-2-carboxamide 
• 167479-16-5 1-methylindolyl-7-carboxylic acid 

Relevant articles and documents

Substituted indole - 2 - formic acid (by machine translation)

This invention relates to a substituted indole - 2 - carboxylic acid synthesis method, is to replace the phenyl hydrazine hydrochloride or arylhydrazines as raw materials, through with pyruvic acid ethyl ester cheng zong, Fischer indole synthesis by reaction of substituted indole - 2 - carboxylic acid ethyl ester, hydrolysis to obtain the substituted - 2 - carboxylic acid. Product purity is greater than 97%, the reaction yield is 64%. Synthesis method of the invention with non-harsh conditions, the operation is simple, and environmental friendliness, it has certain economic benefits. It is a kind of raw materials are easy, simple operation, three wastes, high yield of indole - 2 - carboxylic acid synthesis method. (by machine translation)

HETEROCYCLIC COMPOUNDS

Heterocyclic compounds and methods of making them and using them.

USE OF INDOLYL DERIVATIVES FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT ALLERGIC RHINITIS

A method to treat allergic rhinitis is disclosed in which patients are administered certain indolyl compounds.

The first potent and selective non-imidazole human histamine H4 receptor antagonists

Following the discovery of the human histamine H4 receptor, a high throughput screen of our corporate compound collection identified compound 6 as a potential lead. Investigation of the SAR resulted in the discovery of novel compounds 10e and 10l, which are the first potent and selective histamine H4 receptor antagonists to be described.

Heterocyclic compounds

Heterocyclic compounds and methods of making them and using them.