(+)-Nefopam

Base Information Edit

Chemical Name:(+)-Nefopam
CAS No.:110011-82-0
Molecular Formula:C₁₇H₁₉NO
Molecular Weight:253.344
Hs Code.:
UNII:RJ253LM2KD
DSSTox Substance ID:DTXSID901318213
Nikkaji Number:J292.402A
Wikidata:Q27160182
ChEMBL ID:CHEMBL4748805
Mol file:110011-82-0.mol

Synonyms:(+)-Nefopam;110011-82-0;(S)-nefopam;Nefopam, (S)-;RJ253LM2KD;( )-Nefopam;1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-, (S)-;(1s)-5-methyl-1-phenyl-3,4,5,6-tetrahydro-1h-2,5-benzoxazocine;S-NEFOPAM;UNII-RJ253LM2KD;SCHEMBL466497;CHEMBL4748805;CHEBI:88320;DTXSID901318213;(1S)-5-methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine;1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-, (1S)-;Q27160182;(1S)-1-Phenyl-5-methyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine;(1S)-3,4,5,6-TETRAHYDRO-5-METHYL-1-PHENYL-1H-2,5-BENZOXAZOCINE

Suppliers and Price of (+)-Nefopam

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (+)-Nefopam Edit

Chemical Property:

Vapor Pressure:1.18E-05mmHg at 25°C
Boiling Point:369.5°C at 760 mmHg
Flash Point:109°C
Density:1.064g/cm³
XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:253.146664230
Heavy Atom Count:19
Complexity:274

Purity/Quality:: >95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1CCOC(C2=CC=CC=C2C1)C3=CC=CC=C3
Isomeric SMILES:CN1CCO[C@H](C2=CC=CC=C2C1)C3=CC=CC=C3

Technology Process of (+)-Nefopam

There total 9 articles about (+)-Nefopam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 23327-57-3
nefopam hydrochloride

: 13669-70-0,69319-32-0,91463-82-0,110011-82-0
nefopam

Guidance literature:: With sodium hydroxide; In water; ethyl acetate; for 0.166667h;

Reference yield:

: 60725-36-2
2-[{2-[hydroxyl(phenyl)methyl]benzyl}(methyl)amino]ethanol

: 13669-70-0,69319-32-0,91463-82-0,110011-82-0
nefopam

Guidance literature:: With methanesulfonic acid; In toluene; at 20 - 110 ℃; for 1.5h; Reagent/catalyst; Large scale;
DOI:10.1021/acs.oprd.7b00228

Reference yield:

: 17494-19-8
2,3-dihydro-9b-phenyloxazolo<2,3-a>isoindol-5(9bH)-one

: 13669-70-0,69319-32-0,91463-82-0,110011-82-0
nefopam

Guidance literature:: Multi-step reaction with 3 steps

1: 37 percent / LiAlH₄ / tetrahydrofuran / 30 h / Heating

2: 35 percent / potassium carbonatye / CHCl₃ / 14 h / Heating

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; chloroform;