23327-57-3 Usage
Chemical Properties
White to Off-White Solid
Uses
Different sources of media describe the Uses of 23327-57-3 differently. You can refer to the following data:
1. A cyclized analog of orphenadrine and diphenhydramine; representative of a new class of centrally acting skeletal muscle relaxants, the benzoxazocines. Analgesic; antidepressant.
2. Nefopam hydrochloride has been used as a standard for the quantitative determination of tramadol by gas chromatography–mass spectrometry (GC/MS).
Biochem/physiol Actions
Nefopam is a centrally-acting analgesic drug of the benzoxazocine chemical class. Nefopam is a non-opioid, but has a potentiating effect on morphine and other opioids. Its mechanism of action is not certain, but may involve its action as a dopamine/serotonin/norepinephrine reuptake inhibitor.
Clinical Use
Analgesic for moderate pain
Drug interactions
Potentially hazardous interactions with other drugs
Antidepressants: avoid MAOIs; tricyclics possibly
increased risk of side effects.
Metabolism
Extensively metabolised in the liver to produce active
metabolites.
It is mainly excreted in the urine. About 8% of a dose is
excreted via the faeces.
Check Digit Verification of cas no
The CAS Registry Mumber 23327-57-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,3,2 and 7 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 23327-57:
(7*2)+(6*3)+(5*3)+(4*2)+(3*7)+(2*5)+(1*7)=93
93 % 10 = 3
So 23327-57-3 is a valid CAS Registry Number.
InChI:InChI=1/C17H19NO.ClH/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18;/h2-10,17H,11-13H2,1H3;1H
23327-57-3Relevant articles and documents
Preparation method for nefopam hydrochloride
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, (2018/04/01)
The invention discloses a preparation method for nefopam hydrochloride. The preparation method is characterized by comprising the following preparation steps: (A) performing a reaction on raw materials including tert-butyl N-benzyl-N-methyl carbamate and benzoyl chloride to obtain an intermediate tert-butyl N-(2-(benzoyl)benzyl)-N-methyl carbamate; (B) performing reduction on the intermediate tert-butyl N-(2-(benzoyl)benzyl)-N-methyl carbamate by a reductant, and performing acidolysis to obtain an intermediate 1-((2-(methylamino)methyl)phenyl)-1-phenylmethanol hydrochloride; and (C) performinga reaction on the intermediate 1-((2-(methylamino)methyl)phenyl)-1-phenylmethanol hydrochloride and chloroacetyl chloride to form an amide through a one-pot method, performing cyclization, and performing reduction by a reductant to obtain the objective compound nefopam hydrochloride. According to the invention, the reaction steps are simple, and the preparation method is easy to implement.
RACEMISATION OF ENANTIOMERS OF NEFOPAM AND ANALOGUES
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Page/Page column 4, (2008/06/13)
A process for the racemisation of a compound which is nefopam or an analogue thereof in the form of a single enantiomer or non-racemic mixture, which comprising contacting the compound with an acid.
