11-OXO-11H-PYRIDO[2,1-B]QUINAZOLINE-6-CARBOXYLIC ACID

Base Information

• Chemical Name: 11-OXO-11H-PYRIDO[2,1-B]QUINAZOLINE-6-CARBOXYLIC ACID
• CAS No.: 4393-98-0
• Molecular Formula: C₁₃H₈N₂O₃
• Molecular Weight: 240.218
• Hs Code.: 2933990090
• Mol file: 4393-98-0.mol

Synonyms:11-oxo-11H-pyrido<2,1-b>quinazoline-6-carboxylic acid;Dodecanoic acid,11-oxo-,methyl ester;4-carboxypyrido<2,1-b>quinazolin-10-one;11-oxo-dodecanoic acid methyl ester;11-Oxo-dodecansaeure-methylester;Methyl11-oxolaurate;

Chemical Property of 11-OXO-11H-PYRIDO[2,1-B]QUINAZOLINE-6-CARBOXYLIC ACID

Chemical Property:

• PSA: 71.67000
• LogP: 1.54590

Purity/Quality:

98%min ^*data from raw suppliers

11-Oxo-11H-pyrido[2,1-b]quinazoline-6-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 11-OXO-11H-PYRIDO[2,1-B]QUINAZOLINE-6-CARBOXYLIC ACID

There total 4 articles about 11-OXO-11H-PYRIDO[2,1-B]QUINAZOLINE-6-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-chloronicotinic acid (2942-59-8) + 2-ethoxycarbonylaniline (87-25-2) → 11-oxo-11H-pyrido<2,1-b>quinazoline-6-carboxylic acid (4393-98-0)

Guidance literature:

With acetic acid; for 12h;

DOI:10.1007/BF02226524

Reference yield: 60.0%

2-chloronicotinic acid (2942-59-8) + anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → 11-oxo-11H-pyrido<2,1-b>quinazoline-6-carboxylic acid (4393-98-0)

Guidance literature:

With acetic acid; for 12h;

DOI:10.1007/BF02226524

Reference yield: 54.0%

2-chloronicotinic acid (2942-59-8) + 2-carbomethoxyaniline (134-20-3) → 11-oxo-11H-pyrido<2,1-b>quinazoline-6-carboxylic acid (4393-98-0)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 80 ℃; for 48h;

upstream raw materials:

2-chloronicotinic acid

anthranilic acid

2-ethoxycarbonylaniline

2-carbomethoxyaniline

Downstream raw materials:

N-[2-(dimethylamino)ethyl]-11-oxopyrido[2,1-b]quinazoline-6-carboxamide