1,3-Dioxolane, 2-(2-methoxyphenyl)-

Base Information

• Chemical Name: 1,3-Dioxolane, 2-(2-methoxyphenyl)-
• CAS No.: 4420-21-7
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• DSSTox Substance ID: DTXSID90474039
• Nikkaji Number: J1.092.607F
• Wikidata: Q82303804
• Mol file: 4420-21-7.mol

Synonyms:4420-21-7;1,3-Dioxolane, 2-(2-methoxyphenyl)-;SCHEMBL10761583;DTXSID90474039;AKOS006293773

Chemical Property of 1,3-Dioxolane, 2-(2-methoxyphenyl)-

Chemical Property:

• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 180.078644241
• Heavy Atom Count: 13
• Complexity: 154

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1C2OCCO2

Technology Process of 1,3-Dioxolane, 2-(2-methoxyphenyl)-

There total 5 articles about 1,3-Dioxolane, 2-(2-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethylene glycol (107-21-1) + ortho-anisaldehyde (135-02-4) → 2-(2-methoxyphenyl)-1,3-dioxolane (4420-21-7)

Guidance literature:

With iron(III) chloride; for 0.0333333h; Irradiation;

DOI:10.1080/00397919508015450

Reference yield: 90.0%

1-naphthaldehyde (66-77-3) + orthoformic acid triethyl ester (122-51-0) → 2-(2-methoxyphenyl)-1,3-dioxolane (4420-21-7)

Guidance literature:

With tetra-N-butylammonium tribromide; In ethylene glycol; at 20 ℃; for 20h; Inert atmosphere;

DOI:10.1021/acs.orglett.6b02833

Reference yield: 25.0%

orthoformic acid triethyl ester (122-51-0) + ortho-anisaldehyde (135-02-4) → 2-(2-methoxyphenyl)-1,3-dioxolane (4420-21-7)

Guidance literature:

With tetra-N-butylammonium tribromide; In ethylene glycol; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1021/acs.orglett.6b02833

upstream raw materials:

ethylene glycol

ortho-anisaldehyde

2-chloro-ethanol

orthoformic acid triethyl ester

Downstream raw materials:

2-Methoxybenzoic acid

ortho-anisaldehyde

2-methoxybenzoic acid methyl ester

2-hydroxyethyl 2-methoxybenzoate