1-Piperidinecarboxylic acid, 4-[(6-chloro-2-pyridinyl)oxy]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 1-Piperidinecarboxylic acid, 4-[(6-chloro-2-pyridinyl)oxy]-, 1,1-dimethylethyl ester
• CAS No.: 442199-11-3
• Molecular Formula: C15H21ClN2O3
• Molecular Weight: 312.79200

Synonyms:tert-butyl 4-[(6-chloro-2-pyridyl)oxy]-1-piperidinecarboxylate;tert-butyl 4-((6-chloropyridin-2-yl)oxy)piperidine-1-carboxylate;tert-butyl 4-[(6-chloro-2-pyridinyl)oxy]-1-piperidinecarboxylate;

Chemical Property of 1-Piperidinecarboxylic acid, 4-[(6-chloro-2-pyridinyl)oxy]-, 1,1-dimethylethyl ester

Chemical Property:

• PSA: 51.66000
• LogP: 3.45120

Purity/Quality:

99% ^*data from raw suppliers

Tert-butyl4-[(6-chloro-2-pyridyl)oxy]-1-piperidinecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of 1-Piperidinecarboxylic acid, 4-[(6-chloro-2-pyridinyl)oxy]-, 1,1-dimethylethyl ester

There total 4 articles about 1-Piperidinecarboxylic acid, 4-[(6-chloro-2-pyridinyl)oxy]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2,6-dichloropyridine (2402-78-0) → 4-(6-chloropyridin-2-yloxy)piperidine-1-carboxylic acid tert-butyl ester (442199-11-3)

Guidance literature:

t-butyl 4-hydroxy piperidine-1-carboxylate; With sodium hydride; In dimethyl sulfoxide; for 0.333333h;

2,6-dichloropyridine; In dimethyl sulfoxide; at 110 ℃; for 12h;

Reference yield: 48.0%

2,6-dichloropyridine (2402-78-0) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 4-(6-chloropyridin-2-yloxy)piperidine-1-carboxylic acid tert-butyl ester (442199-11-3)

Guidance literature:

t-butyl 4-hydroxy piperidine-1-carboxylate; With sodium hydride; In tetrahydrofuran; at 60 ℃; for 0.5h;

2,6-dichloropyridine; In tetrahydrofuran; at 20 ℃;

Reference yield:

6-chloro-2-hydroxypyridine (16879-02-0) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 4-(6-chloropyridin-2-yloxy)piperidine-1-carboxylic acid tert-butyl ester (442199-11-3)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 24h;

upstream raw materials:

6-chloro-2-hydroxypyridine

t-butyl 4-hydroxy piperidine-1-carboxylate

2,6-dichloropyridine

Downstream raw materials:

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(6-chloro-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]acrylamide

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