2(1H)-Isoquinolinecarboxylic acid, 3-[[[(1R)-1-[(4-chlorophenyl)methyl]-2-methoxy-2-oxoethyl]amino]methyl] -3,4-dihydro-, 1,1-dimethylethyl ester, (3R)-

Base Information

Chemical Name:2(1H)-Isoquinolinecarboxylic acid, 3-[[[(1R)-1-[(4-chlorophenyl)methyl]-2-methoxy-2-oxoethyl]amino]methyl] -3,4-dihydro-, 1,1-dimethylethyl ester, (3R)-
CAS No.:444583-49-7
Molecular Formula:C25H31ClN2O4
Molecular Weight:458.985
Hs Code.:

2(1H)-Isoquinolinecarboxylic acid,
3-[[[(1R)-1-[(4-chlorophenyl)methyl]-2-methoxy-2-oxoethyl]amino]methyl]
-3,4-dihydro-, 1,1-dimethylethyl ester, (3R)-

Synonyms:

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Chemical Property of 2(1H)-Isoquinolinecarboxylic acid, 3-[[[(1R)-1-[(4-chlorophenyl)methyl]-2-methoxy-2-oxoethyl]amino]methyl] -3,4-dihydro-, 1,1-dimethylethyl ester, (3R)-

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Technology Process of 2(1H)-Isoquinolinecarboxylic acid, 3-[[[(1R)-1-[(4-chlorophenyl)methyl]-2-methoxy-2-oxoethyl]amino]methyl] -3,4-dihydro-, 1,1-dimethylethyl ester, (3R)-

There total 3 articles about 2(1H)-Isoquinolinecarboxylic acid, 3-[[[(1R)-1-[(4-chlorophenyl)methyl]-2-methoxy-2-oxoethyl]amino]methyl] -3,4-dihydro-, 1,1-dimethylethyl ester, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 444583-19-1
tert-butyl (3R)-3-formyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 134166-72-6,24561-03-3
D-p-chlorophenylalanine methyl ester

: 444583-49-7
tert-butyl (3R)-3-({[(1R)-1-(4-chlorobenzyl)-2-methoxy-2-oxoethyl]amino}methyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: With sodium acetate; sodium cyanoborohydride; acetic acid; In methanol;
DOI:10.1016/j.bmcl.2005.10.103

Reference yield:

: 444583-18-0
tert-butyl (3R)-3-{[methoxy(methyl)-amino]carbonyl}-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 444583-49-7
tert-butyl (3R)-3-({[(1R)-1-(4-chlorobenzyl)-2-methoxy-2-oxoethyl]amino}methyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran

2: NaBH₃CN; NaOAc; HOAc / methanol

With lithium aluminium tetrahydride; sodium acetate; sodium cyanoborohydride; acetic acid; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2005.10.103

Reference yield:

: 78879-20-6,144069-68-1,115962-35-1
D-N-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinolinoline-3-carboxylic acid

: 444583-49-7
tert-butyl (3R)-3-({[(1R)-1-(4-chlorobenzyl)-2-methoxy-2-oxoethyl]amino}methyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: EDC; HOBT; DIEA / tetrahydrofuran

2: LiAlH₄ / tetrahydrofuran

3: NaBH₃CN; NaOAc; HOAc / methanol

With lithium aluminium tetrahydride; sodium acetate; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2005.10.103