Carbamic acid, [3-cyano-1-[4-(phenylmethoxy)phenyl]propyl]methyl-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [3-cyano-1-[4-(phenylmethoxy)phenyl]propyl]methyl-, 1,1-dimethylethyl ester
CAS No.:444646-43-9
Molecular Formula:C23H28N2O3
Molecular Weight:380.487
Hs Code.:

Synonyms:

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Chemical Property of Carbamic acid, [3-cyano-1-[4-(phenylmethoxy)phenyl]propyl]methyl-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, [3-cyano-1-[4-(phenylmethoxy)phenyl]propyl]methyl-, 1,1-dimethylethyl ester

There total 9 articles about Carbamic acid, [3-cyano-1-[4-(phenylmethoxy)phenyl]propyl]methyl-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 143-33-9,25596-52-5
sodium cyanide

: 444646-42-8
N-[1-(4-benzyloxyphenyl)-3-hydroxypropyl]-N-methylcarbamic acid tert-butyl ester

: 444646-43-9
N-[1-(4-benzyloxyphenyl)-3-cyanopropyl]-N-methylcarbamic acid tert-butyl ester

Guidance literature:: methanesulfonyl chloride; N-[1-(4-benzyloxyphenyl)-3-hydroxypropyl]-N-methylcarbamic acid tert-butyl ester; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

sodium cyanide; With 15-crown-5; In DMF (N,N-dimethyl-formamide); at 20 ℃;

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 444646-43-9
N-[1-(4-benzyloxyphenyl)-3-cyanopropyl]-N-methylcarbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: ethanol / 2 h / 90 °C

2: sulfuric acid / 6 h / 80 °C

3: tetrahydrofuran / 12 h / 20 °C

4: K₂CO₃ / dimethylformamide / 3 h / 20 °C

5: LiAlH₄ / tetrahydrofuran / 0.17 h / -20 - -10 °C

6: 2.20 g / NaOH / H₂O; methanol / 2 h / 50 °C

7: 1.90 g / K₂CO₃ / acetone / 2 h / 50 °C

8: 2.24 g / Et₃N / tetrahydrofuran / 1 h / 20 °C

9: 1.54 g / 15-crown-5 / dimethylformamide / 12 h / 20 °C

With sodium hydroxide; lithium aluminium tetrahydride; 15-crown-5; sulfuric acid; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 10303-89-6
3-(4-hydroxy-phenyl)-3-methylamino-propionic acid

: 444646-43-9
N-[1-(4-benzyloxyphenyl)-3-cyanopropyl]-N-methylcarbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: sulfuric acid / 6 h / 80 °C

2: tetrahydrofuran / 12 h / 20 °C

3: K₂CO₃ / dimethylformamide / 3 h / 20 °C

4: LiAlH₄ / tetrahydrofuran / 0.17 h / -20 - -10 °C

5: 2.20 g / NaOH / H₂O; methanol / 2 h / 50 °C

6: 1.90 g / K₂CO₃ / acetone / 2 h / 50 °C

7: 2.24 g / Et₃N / tetrahydrofuran / 1 h / 20 °C

8: 1.54 g / 15-crown-5 / dimethylformamide / 12 h / 20 °C

With sodium hydroxide; lithium aluminium tetrahydride; 15-crown-5; sulfuric acid; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone;