[(4-methoxyphenyl)methylidyne]azane oxide

Base Information

• Chemical Name: [(4-methoxyphenyl)methylidyne]azane oxide
• CAS No.: 15500-73-9
• Molecular Formula: C8H7 N O2
• Molecular Weight: 149.149
• Mol file: 15500-73-9.mol

Synonyms:p-Anisonitrile,N-oxide (8CI); 4-Methoxybenzonitrile N-oxide; 4-Methoxybenzonitrile oxide;Anisonitrile oxide; p-Anisonitrile oxide; p-Methoxybenzonitrile N-oxide;p-Methoxybenzonitrile oxide

Chemical Property of [(4-methoxyphenyl)methylidyne]azane oxide

Chemical Property:

• Density: 1.06g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [(4-methoxyphenyl)methylidyne]azane oxide

There total 9 articles about [(4-methoxyphenyl)methylidyne]azane oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-hydroxy-4-methoxy-benzenecarboximidoyl chloride (38435-51-7) → 4-methoxybenzonitrile oxide (15500-73-9)

Guidance literature:

With triethylamine; In diethyl ether; at -15 ℃;

Reference yield:

p-methoxyl benzaldoxime (3717-21-3,3717-22-4,140461-28-5,140461-29-6,3235-04-9) → 4-methoxybenzonitrile oxide (15500-73-9)

Guidance literature:

With chloroamine-T; In ethanol; for 0.0333333h; Ambient temperature;

DOI:10.1080/00397919708006048

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → 4-methoxybenzonitrile oxide (15500-73-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; sodium hydroxide / water; tert-butyl alcohol / 4 h / 20 °C

2: chloroamine-T / water; tert-butyl alcohol / 0.05 h / 20 °C

With hydroxylamine hydrochloride; chloroamine-T; sodium hydroxide; In water; tert-butyl alcohol;

DOI:10.1021/jm1008715

upstream raw materials:

N-hydroxy-4-methoxy-benzenecarboximidoyl chloride

p-methoxyl benzaldoxime

N-hydroxy-4-methoxybenzenecarboximidoyl chloride

4-methoxy-benzaldehyde

Downstream raw materials:

3-(4-methoxyphenyl)-5-phenylisoxazole

3-(4-methoxy-phenyl)-5-nitro-4,5-dihydro-isoxazole

3-(4-methoxy-phenyl)-5-methylisoxazole

3-(4-methoxy-phenyl)-8b-pyrrolidin-1-yl-3a,8b-dihydro-benzo[4,5]furo[2,3-d]isoxazole

Refernces

• 1、 Nicolaides,Fylaktakidou,Litinas,Papageorgiou,Hadjipavlou-Litina. "1,3-Cycloaddition reactions of 2-oxo-2H-[1]benzopyran-4-carbonitrile N- oxide. Synthesis of several new 4-substituted coumarins". . p. 619 - 625. Retrieved 1998.
• 2、 Polat-Cakir, Sidika. "1,3-Dipolar cycloaddition reactions of acyl phosphonates with nitrile oxides: synthesis of phosphonate-containing dioxazole derivatives". . p. 461 - 467. Retrieved 2020.
• 3、 Karthik, B.,Kumar, A. Kannan,Nukala, Satheesh Kumar,Ravinder, M.,Swamy, T. Narasimha. "One-Pot Regioselective Synthesis of 7-Bromo-2H-Benzo[b][1,4]Oxazin-3(4H)-One Linked Isoxazole Hybrids as Anti-Cancer Agents and Their Molecular Docking Studies". . p. 1269 - 1275. Retrieved 2021/12/23.