1-(2-Aminopyridin-4-yl)-2-(4-fluorophenyl)ethanone

Base Information

Chemical Name:1-(2-Aminopyridin-4-yl)-2-(4-fluorophenyl)ethanone
CAS No.:452056-80-3
Molecular Formula:C13H11FN2O
Molecular Weight:230.242
Hs Code.:
DSSTox Substance ID:DTXSID30454330
Nikkaji Number:J2.572.051B
Wikidata:Q82275796
Mol file:452056-80-3.mol

Synonyms:1-(2-aminopyridin-4-yl)-2-(4-fluorophenyl)ethanone;452056-80-3;SCHEMBL2842825;DTXSID30454330;IOXAEZSQRZMYNX-UHFFFAOYSA-N;2-Amino-4-(4-fluorophenylacetyl)pyridine;2-(4-Fluorophenyl)-1-(2-amino-4-pyridyl)ethanone;1-(2-amino-4-pyridinyl)-2-(4-fluorophenyl)-Ethanone;1-(2-aminopyridin-4-yl)-2-(4-fluorophenyl)ethan-1-one

Suppliers and Price of 1-(2-Aminopyridin-4-yl)-2-(4-fluorophenyl)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
1-(2-Aminopyridin-4-yl)-2-(4-fluorophenyl)ethanone 95+%
1g
$ 535.00

Chemenu
1-(2-aminopyridin-4-yl)-2-(4-fluorophenyl)ethan-1-one 95%
1g
$ 505.00

American Custom Chemicals Corporation
1-(2-AMINOPYRIDIN-4-YL)-2-(4-FLUOROPHENYL)ETHANONE 95.00%
5MG
$ 495.65

Alichem
1-(2-Aminopyridin-4-yl)-2-(4-fluorophenyl)ethanone
1g
$ 453.44

Total 13 raw suppliers

Chemical Property of 1-(2-Aminopyridin-4-yl)-2-(4-fluorophenyl)ethanone

Chemical Property:

Melting Point:157.0℃
PSA：56.71000
LogP:2.15840
Storage Temp.:2-8°C
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:230.08554114
Heavy Atom Count:17
Complexity:264

Purity/Quality:

99.3% ^*data from raw suppliers

1-(2-Aminopyridin-4-yl)-2-(4-fluorophenyl)ethanone 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1CC(=O)C2=CC(=NC=C2)N)F

Technology Process of 1-(2-Aminopyridin-4-yl)-2-(4-fluorophenyl)ethanone

There total 6 articles about 1-(2-Aminopyridin-4-yl)-2-(4-fluorophenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 452056-79-0
N-{4-[2-cyano-2-(4-fluorophenyl)acetyl]pyridin-2-yl}acetamide

: 452056-80-3
1-(2-aminopyridin-4-yl)-2-(4-fluorophenyl)ethanone

Guidance literature:: N-{4-[2-cyano-2-(4-fluorophenyl)acetyl]pyridin-2-yl}acetamide; With water; hydrogen bromide; for 30h; Heating / reflux;

With ammonia; In water; at 0 ℃;

Reference yield: 55.0%

: 549505-57-9
N-{4-[2-cyano-2-(4-fluoro-phenyl)-1-hydroxy-vinyl]-pyridin-2-yl}-acetamide

: 452056-80-3
1-(2-aminopyridin-4-yl)-2-(4-fluorophenyl)ethanone

Guidance literature:: With hydrogen bromide; In water; for 30h; Heating;
DOI:10.1021/jo026619w

Reference yield:

: 459-22-3
4-fluorophenylacetonitrile

: 452056-80-3
1-(2-aminopyridin-4-yl)-2-(4-fluorophenyl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: carbonyldiimidazole / tetrahydrofuran / 0.75 h / 20 °C

1.2: 62 percent / KOt-Bu / tetrahydrofuran / 2 h / 120 °C

2.1: 50 percent / aq. HBr / 30 h / Heating

With hydrogen bromide; 1,1'-carbonyldiimidazole; In tetrahydrofuran;
DOI:10.1021/jm0496584