N-{4-[4-(4-fluorophenyl)-1-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}acetamide

Base Information

• Chemical Name: N-{4-[4-(4-fluorophenyl)-1-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}acetamide
• CAS No.: 452056-93-8
• Molecular Formula: C₁₈H₁₇FN₄OS
• Molecular Weight: 356.424

Synonyms:N-{4-[4-(4-fluorophenyl)-1-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}acetamide

Chemical Property of N-{4-[4-(4-fluorophenyl)-1-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}acetamide

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Technology Process of N-{4-[4-(4-fluorophenyl)-1-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}acetamide

There total 15 articles about N-{4-[4-(4-fluorophenyl)-1-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

C17H15FN4OS (452056-88-1) + methyl iodide (74-88-4) → N-{4-[4-(4-fluorophenyl)-1-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}acetamide (452056-93-8)

Guidance literature:

With sodium carbonate; In ethanol; Heating / reflux;

Reference yield: 63.0%

N-{4-[4-(4-fluorophenyl)-1-methyl-2-thioxo-2,3-dihydro-1H-imidazol-5-yl]pyridin-2-yl}acetamide (452056-88-1) + methyl iodide (74-88-4) → N-{4-[4-(4-fluorophenyl)-1-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}acetamide (452056-93-8)

Guidance literature:

With sodium carbonate; In ethanol; Heating / reflux;

Reference yield: 52.0%

N-{4-[4-(4-fluorophenyl)-1-methyl-2-thioxo-2,3-dihydro-1H-imidazol-5-yl]pyridin-2-yl}acetamide (452056-88-1) + methyl iodide (74-88-4) → N-{4-[4-(4-fluorophenyl)-1-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}acetamide (452056-93-8) + 4-(2-acetylamino-pyridin-4-yl)-5-(4-fluoro-phenyl)-1,3-dimethyl-2-methylsulfanyl-3H-imidazol-1-ium; iodide

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 20h;

DOI:10.1021/jo026619w

upstream raw materials:

N-{4-[4-(4-fluorophenyl)-1-methyl-2-thioxo-2,3-dihydro-1H-imidazol-5-yl]pyridin-2-yl}acetamide

methyl iodide

2-Amino-4-methylpyridine

2-acetylamino-4-methylpyridine

Downstream raw materials:

4-[4-(4-fluorophenyl)-1-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-ylamine

N-{4-[4-(4-fluorophenyl)-1-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}-N-(1-phenylethyl)amine

N-{4-[5-(4-fluoro-phenyl)-3-methyl-2-methylsulfinyl-3H-imidazol-4-yl]-pyridin-2-yl}-acetamide

N-{4-[5-(4-fluoro-phenyl)-3-methyl-2-methylsulfinyl-3H-imidazol-4-yl]-pyridin-2-yl}-acetamide

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