N-{4-[4-(4-fluorophenyl)-1-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}-N-(1-phenylethyl)amine

Base Information

Chemical Name:N-{4-[4-(4-fluorophenyl)-1-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}-N-(1-phenylethyl)amine
CAS No.:549505-58-0
Molecular Formula:C₂₄H₂₃FN₄S
Molecular Weight:418.538
Hs Code.:

Synonyms:N-{4-[4-(4-fluorophenyl)-1-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}-N-(1-phenylethyl)amine

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Chemical Property of N-{4-[4-(4-fluorophenyl)-1-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}-N-(1-phenylethyl)amine

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Technology Process of N-{4-[4-(4-fluorophenyl)-1-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}-N-(1-phenylethyl)amine

There total 11 articles about N-{4-[4-(4-fluorophenyl)-1-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}-N-(1-phenylethyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 585-71-7,38661-81-3
(1-bromoethyl)benzne

: 452056-98-3
4-[4-(4-fluorophenyl)-1-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-ylamine

: 549505-58-0
N-{4-[4-(4-fluorophenyl)-1-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}-N-(1-phenylethyl)amine

Guidance literature:: 4-[4-(4-fluorophenyl)-1-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-ylamine; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

(1-bromoethyl)benzne; In N,N-dimethyl-formamide; for 8h; Heating;
DOI:10.1021/jo026619w

Reference yield: 20.0%

: 549505-65-9
ML 3403

: 74-88-4
methyl iodide

: N-{4-[5-(4-fluorophenyl)-1-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}-N-(1-phenylethyl)amine

: 549505-58-0
N-{4-[4-(4-fluorophenyl)-1-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}-N-(1-phenylethyl)amine

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jo026619w

Reference yield:

: 695-34-1
2-Amino-4-methylpyridine

: 549505-58-0
N-{4-[4-(4-fluorophenyl)-1-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}-N-(1-phenylethyl)amine

Guidance literature:: Multi-step reaction with 11 steps

1.1: 75 percent / 4-dimethylaminopyridine / 5 h / Heating

2.1: 42 percent / potassium permanganate / H₂O / 2.5 h / 50 - 90 °C

3.1: carbonyldiimidazole / dimethylformamide / 0.75 h / 20 °C

3.2: 65 percent / potassium tert-butoxide / dimethylformamide / 2 h / 120 °C

4.1: 55 percent / HBr / H₂O / 30 h / Heating

5.1: 94 percent / 4-dimethylaminopyridine / 5 h / Heating

6.1: 54 percent / NaOMe; isoamyl nitrite / methanol / 2 h / 20 °C

7.1: ethanol / 7 h / Heating

8.1: 2.2 g / 2,2,4,4-tetramethylcyclobutane-1,3-dithione / CH₂Cl₂ / 1 h / 20 °C

9.1: 52 percent / K₂CO₃ / methanol / 20 h / 20 °C

10.1: 82 percent / HCl / H₂O / 14 h / Heating

11.1: NaH / dimethylformamide / 1 h / 20 °C

11.2: 32 percent / dimethylformamide / 8 h / Heating

With hydrogenchloride; dmap; potassium permanganate; 2,2,4,4-tetramethylcyclobutane-1,3-dithione; hydrogen bromide; sodium methylate; sodium hydride; potassium carbonate; 1,1'-carbonyldiimidazole; isopentyl nitrite; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo026619w