1-(1-Pyrrolidyl)-1-propanone

Base Information

• Chemical Name: 1-(1-Pyrrolidyl)-1-propanone
• CAS No.: 4553-05-3
• Molecular Formula: C7H13NO
• Molecular Weight: 127.186
• Hs Code.: 2933990090
• Mol file: 4553-05-3.mol

Synonyms:Pyrrolidiniumpropionamide;pyrrolidinepropionamide;1-(1'-oxopropyl)pyrrolidine;N-Propanoylpyrrolidine;1-propionylpyrrolidine;propionic acid pyrrolidide;

Chemical Property of 1-(1-Pyrrolidyl)-1-propanone

Chemical Property:

• PSA: 20.31000
• LogP: 0.95670

Purity/Quality:

95% ^*data from raw suppliers

1-(1-pyrrolidinyl)-1-Propanone 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(1-Pyrrolidyl)-1-propanone

There total 1 articles about 1-(1-Pyrrolidyl)-1-propanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyrrolidine (123-75-1) + 1-(3,5-dimethyl-1H-pyrazol-1-yl)propan-1-one (37612-61-6) → 3,5-dimethyl-1H-pyrazole (67-51-6) + 1-pyrrolidin-1-yl-propan-1-one (4553-05-3)

Guidance literature:

In benzene; at 29.5 ℃; Rate constant; other pyrazol, other amines;

DOI:10.3987/COM-94-6711

Reference yield: 97.0%

1-pyrrolidin-1-yl-propan-1-one (4553-05-3) + vinyltriphenylsilane (18666-68-7) → 2-methyl-1-(pyrrolidin-1-yl)-4-(triphenylsilyl)butan-1-one

Guidance literature:

vinyltriphenylsilane; With 18-crown-6 ether; potassium hexamethylsilazane; at 25 ℃; for 0.5h; Inert atmosphere;

1-pyrrolidin-1-yl-propan-1-one; at 25 ℃; for 6h; Inert atmosphere;

DOI:10.1039/c8ob00941d

Reference yield: 93.0%

1-pyrrolidin-1-yl-propan-1-one (4553-05-3) + dimethyltitanocene (1271-66-5) → 1,1-dibromo-butan-2-one (3479-86-5) + 1-Bromo-2-butanone (816-40-0)

Guidance literature:

1-pyrrolidin-1-yl-propan-1-one; dimethyltitanocene; In toluene; at 65 ℃; Schlenk technique; Inert atmosphere;

With bromine; In toluene; at -78 ℃; for 0.0333333h; Schlenk technique; Inert atmosphere;

With water; In toluene; at 20 ℃; for 1h; regioselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1080/00397911.2013.765484

upstream raw materials:

pyrrolidine

1-(3,5-dimethyl-1H-pyrazol-1-yl)propan-1-one

Downstream raw materials:

(2'RS,3'RS)-1-(2',3'dimethyl-1',5'-dioxo-5'(2,4,6-trimethylphenyl)pentyl)pyrrolidine

(E,2'RS,3'RS)- and (E,2'RS,3'SR)-1-(3'-hydroxy-2'-methyl-1'-oxo-3'-phenyl-4'-hexenyl)pyrrolidine

(2'RS,3'RS)- and (2'RS,3'SR)-1-(2',3'-dimethyl-1',5'-dioxo-5'-phenylpentyl)pyrrolidine

(2'RS,3'RS)-1-(2',3'-dimethyl-1',5'-dioxo-5'-phenylpentyl)pyrrolidine

Refernces