37612-61-6

Basic information

• Product Name: 3,5-Dimethyl-1-(1-Oxopropyl)-1H-Pyrazole
• Synonyms: 3,5-Dimethyl-1-(1-Oxopropyl)-1H-Pyrazole;1H-Pyrazole, 3,5-dimethyl-1-(1-oxopropyl)-
• CAS NO: 37612-61-6
• Molecular Formula: C₈H₁₂N₂O
• Molecular Weight: 152.19368
• Mol File: 37612-61-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,5-Dimethyl-1-(1-Oxopropyl)-1H-Pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dimethyl-1-(1-Oxopropyl)-1H-Pyrazole(37612-61-6)
• EPA Substance Registry System: 3,5-Dimethyl-1-(1-Oxopropyl)-1H-Pyrazole(37612-61-6)

Safety Data

• Hazardous Substances Data: 37612-61-6(Hazardous Substances Data)

Usage

General Description

3,5-Dimethyl-1-(1-oxopropyl)-1H-pyrazole is a chemical compound with the molecular formula C8H12N2O. It is a pyrazole derivative with a methyl group at the 3 and 5 positions, and a 1-oxopropyl group at the 1 position of the pyrazole ring. 3,5-Dimethyl-1-(1-Oxopropyl)-1H-Pyrazole is often used as an intermediate in the synthesis of pharmaceuticals and agrochemicals, and it has also been studied for its potential biological activities. The presence of the pyrazole ring in the molecule suggests that it may have some biological activity, and further research is needed to determine its potential applications in the pharmaceutical and agrochemical industries.

Upstream product

• 67-51-6 3,5-dimethyl-1H-pyrazole 
• 5818-15-5 d'hydrazide de l'acide propionique 
• 123-54-6 acetylacetone 
• 60-29-7 diethyl ether 
• 79-03-8 propionyl chloride 
• 7732-18-5 water 
• 53009-14-6 3,5-dimethyl-5-hydroxy-Δ²-isoxazoline 
• 10199-63-0 1-(3,5-dimethyl-1H-pyrazol-1-yl)ethanone 
• 74-88-4 methyl iodide 

Downstream Products

• 67-51-6 3,5-dimethyl-1H-pyrazole 
• 4553-05-3 1-pyrrolidin-1-yl-propan-1-one 
• 3217-86-5 N-propyl propanamide 
• 2759-55-9 N-p-tolylpropionamide 
• 2760-31-8 N-(4-methoxyphenyl)-propanamide 
• 10601-63-5 N-(isopropyl)propionamide 
• 1118-32-7 N-tert-butylpropionamide 
• 1114-51-8 N,N-diethylpropanamide 
• 620-71-3 N-(phenyl)-2-methylacetamide 
• 34317-21-0 N-benzyl-N-methylpropionamide 
• 70623-01-7 N-[cyclopropyl(phenyl)methyl]propionamide 
• 10264-12-7 N-benzylpropanamide 
• 10253-95-9 N-(diphenylmethyl)-propylamide 
• 4949-44-4 ethyl propanoylacetate 

Relevant articles and documents

Enantio- and Site-Selective α-Fluorination of N-Acyl 3,5-Dimethylpyrazoles Catalyzed by Chiral π–CuII Complexes

Catalytic enantioselective α-fluorination reactions of carbonyl compounds are among the most powerful and efficient synthetic methods for constructing optically active α-fluorinated carbonyl compounds. Nevertheless, α-fluorination of α-nonbranched carboxylic acid derivatives is still a big challenge because of relatively high pKa values of their α-hydrogen atoms and difficulty of subsequent synthetic transformation without epimerization. Herein we show that chiral copper(II) complexes of 3-(2-naphthyl)-l-alanine-derived amides are highly effective catalysts for the enantio- and site-selective α-fluorination of N-(α-arylacetyl) and N-(α-alkylacetyl) 3,5-dimethylpyrazoles. The substrate scope of the transformation is very broad (25 examples including a quaternary α-fluorinated α-amino acid derivative). α-Fluorinated products were converted into the corresponding esters, secondary amides, tertiary amides, ketones, and alcohols with almost no epimerization in high yield.

Copper-catalyzed C–N cross-coupling of arylboronic acids with N-acylpyrazoles

A copper-catalyzed C–N bond forming reaction of arylboronic acids and N-acylpyrazoles was developed. This procedure used N-acetyl protected pyrazoles as starting material instead of free pyrazoles (NH). The reaction worked under neutral conditions and did not require any base or ligand. The reaction showed good functional group tolerance.

Ring-ring tautomerism in 1,3-alkanoylhydrazonoximes of acetylacetone

The coexistence in solution of tautomeric isoxazoline and pyrazoline forms of 1,3-alkanoylhydrazonoxime of acetylacetone has been detected and investigated by 1H and 13C NMR spectroscopic methods. The compounds indicated eliminate hydroxylamine under the action of acid catalysts, forming 1-acyl-3,5-dimethylpyrazoles.