Technology Process of Benzenemethanamine, N-[(1R)-2-fluoro-1-methylethyl]-
There total 5 articles about Benzenemethanamine, N-[(1R)-2-fluoro-1-methylethyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(4R)-3-benzyl-4-methyl-1,2,3-oxathiazolidine 2,2-dioxide;
With
tetrabutyl ammonium fluoride;
In
acetonitrile;
at 20 ℃;
for 0.5h;
With
sulfuric acid;
In
diethyl ether;
at 20 ℃;
for 2h;
DOI:10.1055/s-2002-25766
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 69 percent / Et3N; SOCl2 / CH2Cl2 / -78 - 20 °C
2.1: 52 percent / aq. NaIO4 / RuCl3*3H2O / acetonitrile / 2.17 h
3.1: TBAF / acetonitrile / 0.5 h / 20 °C
3.2: 77 percent / aq. H2SO4 / diethyl ether / 2 h / 20 °C
With
sodium periodate; thionyl chloride; tetrabutyl ammonium fluoride; triethylamine;
ruthenium trichloride;
In
dichloromethane; acetonitrile;
DOI:10.1055/s-2002-25766
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: benzene / 4 h / Heating
2.1: NaBH4 / methanol / 2 h / 0 °C
3.1: 69 percent / Et3N; SOCl2 / CH2Cl2 / -78 - 20 °C
4.1: 52 percent / aq. NaIO4 / RuCl3*3H2O / acetonitrile / 2.17 h
5.1: TBAF / acetonitrile / 0.5 h / 20 °C
5.2: 77 percent / aq. H2SO4 / diethyl ether / 2 h / 20 °C
With
sodium tetrahydroborate; sodium periodate; thionyl chloride; tetrabutyl ammonium fluoride; triethylamine;
ruthenium trichloride;
In
methanol; dichloromethane; acetonitrile; benzene;
DOI:10.1055/s-2002-25766
